Harold P de Vladar

Mathematical Biology

Royal Holloway University of London







a personal view on global problems


(2009) PhD Mathematical and Natural Sciences.

(2003) MSc in Applied Mathematics.

(1999) Biologist (+ minor in physics).




Research topics


Barton, N.H. and de Vladar, H.P. "Statistical Mechanics and the Evolution of Polygenic Quantitative Traits" Genetics 18(3):997-1011, 2009 doi:10.1534/genetics.108.099309
[ abs | pdf | supplement | highlights ]

de Vladar, H.P. and Pen, I. "Determinism, Noise, and Spurious Estimations in a Generalised Model of Population Growth" Physica A 373:477-485, 2007 doi:10.1016/j.physa.2006.06.025
[ abs | pdf | preprint ]

de Vladar, H.P. "Density-Dependence as a Size-Independent Regulatory Mechanism" J. Theor. Biol. 238(2):245-256, 2006 doi:10.1016/j.jtbi.2005.05.014
[ abs | pdf | preprint ]

de Vladar, H.P., Cipriani, R., Scharifker, B. and Bubis, J. "A Mechanism for the Prebiotic Emergence of Proteins" 83-87 in Seckbach, J; Chela-Flores, J.; Owen, T.; Raulin, F. (Eds.) Life in the Universe From the Miller Experiment to the Search for Life on Other Worlds Series: Cellular Origin, Life in Extreme Habitats and Astrobiology, Vol. 7. Kluwer Academic Publishers, Dordrecht, The Netherlands. 2004, XXX, 374 p. ISBN: 1-4020-2371-5 / 1-4020-3093-2
[ abs | book | preprint ]

de Vladar, H.P. and González, J.A. "Dynamic response of cancer under the influence of immunological activity and therapy" J.Theor.Biol. 227(3):335-348, 2004. doi:10.1016/j.jtbi.2003.11.012
[ abs | pdf | preprint | comment | response ]

González, J.A., de Vladar, H.P. and Rebolledo, T.M. "New Late Intensification Schedules for Cancer Treatmens" Acta Cientif. Venez. 54(4):263-273 , 2003.
[ pdf | interview ]

Papers in preparation

de Vladar, H.P. and Pen, I. "Evolution of Polygenic Traits: Adaptation at Maximal Entropy." (in preparation)

P. de Vladar, H. "Prebiotic alternatives for the synthesis of amino acids and other related compounds" (in spanish) Proceedings of the meeting "Ab Initio Origins of the Universe, Life, and Intelligence." (in press) [ ]

Academic Material & White Papers

P. de Vladar, H.P. Introducción a la Bioinformática. (Guía del Curso Básico de Bioinformática). (draft, in spanish)
[ pdf ]

González, J.A., P. de Vladar, H. and Rebolledo, T.M. "Cancer dynamics described by the Gompertz equation with different cell-kill functions"
[ ]

P. de Vladar, H., Cipriani, R. and Rebolledo, T.M. "On the intrinsic Parametric Constraint of Survival Curves"
[ ]

Colaborators & Friends

Nick Barton Ananías A. Escalante Ma Elena Márquez
Roberto Cipriani
Jorge A. González Ido R. Pen
Omar Cornejo Susana Lobos Leonardo Trujillo




Current Address


Permanent Address



Mathematical Biology Group
School of Biological Sciences
Royal Holloway, University of London
Egham, Surrey TW20 0EX
United Kingdom

Centro de Biociencias,
Fundación Instituto de Estudios
Avanzados - IDEA
Aptdo Postal 17606
Parque Central
Caracas 1015-A



Email Address:

harold . vladar  [ a t ]  rhul . ac . uk


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