TREATMENT OF PSYCHOSIS

DEFINITIONS

§    PSYCHOSIS

l    Loss of contact with reality

l    Distortion of mental capacity

l    Interferes with capacity to cope

§    SYMPTOMS

l    Hallucinations

l    Delusion

BIOCHEMICAL CAUSE

§    DOPAMINERGIC EFFECT

l    OVERPRODUCTION OF DOPAMINE

l    OVERSTIMULATION OF DOPAMINE RECEPTORS

BIOCHEMICAL CONSIDERATIONS

§    BALANCE OF DOPAMINE AND ACETYLCHOLINE RECEPTOR STIMULATION

§    IMBALANCE SYMPTOMS

l    Parkinson-like Syndrome (EPS)

l    Acute Dystonic Reaction

§    TARDIVE DYSKINESIA

l    Not treatable adverse reaction

THERAPEUTIC SIDE EFFECTS

§    SEDATION

§    HYPOTENSION

§    TACHYCARDIA

§    PHOTOSENSITIVITY

§    DECREASED SEIZURE THRESHOLD

§    ANTICHOLINERGIC - dry mouth, blurry vision, dry eye, constipation, urinary retention

PHENOTHIAZINES

§    ALIPHATIC

l    Low potency, high sedation

l    High anticholinergic, low EPS

§    PIPERAZINE

l    High Potency, Low Anticholinergic

§    PIPERADINE

l    Low Potency, High Anticholinergic

MISCELLANEOUS AGENTS

§    BUTYROPHENONE

l    High Potency, Low Anticholinergic

§    DIBENZOXAZEPINE

l    Clozapine - special use procedure, no tardive dyskinesia

§    BENZISOXAZOLE

l    less tardive dyskinesia

THERAPEUTIC USE

§    PSYCHOSIS

 

§    ANTI-EMETIC

 

§    INTRACTABLE HICCUPS