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Abstract |
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The Protective Effect of
Vitamin C on Irradiated Testes of Albino Rat. Lotfy Sayed*, Esam Eldin
Abdel Hady*, Hosam Eldin Hussin*, Atef Ibrahim* and Ola Abdelhamid** *Departments of Anatomy and Histology, Faculty of Medicine, ALAZHAR University ** Anatomy Department, Faculty of Medicine, ALAZHAR University (Girls) Abstract
The increased
exposure to radiation in medicine or industries increases the hazards of
radiation on various organs of the human body. The aim of this work was to evaluate the protective effect of anti oxidant (vitamin C) against the effect of radiation on rat testes. Thirty adult albino
rats were divided into three groups, each contained ten rats .The first group
(G.1) was exposed to 415 r (G.1') or 622 r (G.1") using x-ray source for
one minute per day for one week. The second group (G.2) was exposed to 415 r
(G.2') or 622 r (G.2") using x-ray source for one minute per day for one
week, in addition to vitamin C equivalent to 86.9 mg./liter orally for the two
sub groups for the same period . The third group (G.3) was a control group. The examined testes
of G.1 showed damaged germinal epithelium with remaining some layers of
spermatogonia. There was no affection of spermatocytes, mature sperms, Sertoli
cells and Leydig cells, the lumen contained little sperms and debris of germ
cells (G.1') .While for (G.1") there was marked damage of the
seminiferous tubules with irregular outline, destruction of spermatogonia,
spermatocytes and spermatids with pyknotic type of nuclear degeneration and
the lumen was devoid of mature sperms. The examined testes of the (G.2) showed
evidence of almost complete recovery for G .2' and marked recovery for
G.2" It is concluded
that anti oxidants were essential to patients exposed to x-ray , to guard
against its hazards. |
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