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Abstract |
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Effect Of Diazepam On The
Prenatal Development Of Neuropil Of The Purkinje Cell Layer Of The Cerebellar
Cortex Of The Rats Embryo (Electron Microscope Study) Lotfy Sayed**, Mamdoh
Ghalli**, Essam El-Din Abdelhady* Ola Abdelhamid*** and Reda
Awadalla* Anatomy Department*, Histology Department** Faculty of Medicine, Al-Azhar University Anatomy Department*** Faculty of Medicine, Al-Azhar University (Girls) Abstract Diazepam is one of the most widely
used sedative hypnotic agents, and many women take this drug during pregnancy. The purpose of this study was to
investigate the effects of diazepam on the development of the neuropil of the
Purkinje cell layer of the cerebellar cortex. Twenty female pregnant rats
were used in this study. The rats were divided into two groups, the first
group (5 rats) was used as control group and the second group (15 rats) were
given 10 mg/kg/day of diazepam orally and sacrificed at 15th, 20th,
25th days of pregnancy. It was difficult to differentiate between
the dendrites and the axonal knobs at 15th day of pregnancy. As age
advanced, the dendrites were swollen with absence of cytoplasmic organelles or
contained few free ribosomes and immature mitochondria. The observed axonal
knobs contained ill-defined synaptic vesicles. Immature axo-dendritic synapses
were recognized on the 15th and 20th days of pregnancy,
while on the 25th days of pregnancy symmetrical axo-dendritic
synapses were recognized. From this study, it appears that the exposure to
diazepam causes marked changes on prenatal development of neuropil of the
Purkinje cell layer of the cerebellar cortex.
Aim of the work The aim of the work was to
study the effects of diazepam on the development of the neuropil of Purkinje
cell layer of the cerebellar cortex. |
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