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Abstract |
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Effect of some medicinal plants on liver and kidney functions in diabetic albino rats Eman
G. E. Helal*, Ashraf Mahmoud
**,
Mervat Abdel-Rahman***, and
Anwaar A. Kahwash* *
Zoology Department, Faculty of Science, Al-Azher University (Girls) **
Histology Department, Faculty of Medicine, Al-Azher University **Clinical
Pathology Lab., Student Hospital, Cairo University, Giza. Abstract
The present study aimed to clarify the effect of aqueous extracts of
five plants (Nigella sativa , Aloe vera, Ferula assafoetida, Boswellia
carterii Birdw and Commiphora myrrha) and their mixture on liver and kidney
functions and protein profiles. Eighty adult male albino rats were divided
into eight groups, the first served as control group, other groups were
injected with alloxan(120mg/kg b.wt). The second group served as diabetic
rats, the third were treated with a mixture (0.1g/100g b.wt), the fourth was
treated with Nigella sativa (0.1g/100g b.wt), the fifth was treated with Aloe
vera (0.05 g/100g b.wt ), the sixth was treated with Ferula assafoetida
(0.1g/100g b.wt), the seventh was treated with
Boswellia carterri Birdw (0.1g/100g b.wt) and the eighth group was
treated with Commiphora myrrha (0.05 g/100g b.wt ). After thirty days of
treatment half of each group was decapitated and the other one was left for 15
days without any additional treatment as recovery period to followup their
hazards if present.
The results revealed highly significant increase (p<0.01) in serum
transaminases
(aspartate ( AST ) and alanine (ALT)), alkaline phosphates (ALP), total
bilirubin, urea and creatinine and recorded highly significant decrease
(p<0.01) in serum total protein , albumin and globulin concentrations in
the diabetic group when compared with normal rates. Otherwise, all plants
extracts treated groups showed insignificant changes in the previous
parameters when compared with control one .
It seams, therefore that the water extracts of these plants and their
mixture have protective effect against the side effects of alloxan on liver
and kidney. |
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