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Abstract |
Histological
Study Of The Effect Of Zinc Sulphate On The Toxicity Of Aluminium Sulphate In
Liver And Kidney Of Male Albino Rats
Department of zoology,
Faculty of Science, Cairo University, Cairo, Egypt
Aluminium (Al) is one of the most
abundant and important elements in the environment. In recent years, the
production of this metal and its toxicity increased with its discharge into the
environment. This study was designed to evaluate the effect of Al intake
toxicity in liver and kidney tissues of albino rats and the role of zinc as a
protective agent against Al toxicity.
Fourty five male
albino rats were divided into equal three groups. The first group of animals was
considered as control. The animals in the second group were given (50mg/kg/day)
of Al sulphate orally using gastric tube for 45 day. Third group were given Al
sulphate (50mg/kg/day) followed by zinc sulphate (50mg/kg/day) orally as well as
samples of liver and kidney tissues were obtained after 15, 30, 45 days of last
doses respectively. Paraffin sections (5μm) were prepared for
histological study stained with Haematoxylin & Eosin.
The obtained
histological results of the histological study of the second group showed that
there were congested blood sinusoids and swelling of some hepatocytes within
cytoplasm in which there were vacuoles, fragmented nuclei with some cellular
infiltration. Kidney tissue showed shrinkage of some glomeruli and distortion of
the tubular epithelial cells. Results in the third group, where zinc sulphate
was added, showed amelioration and improvement in both liver and kidney tissues.
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