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Abstract |
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Interaction of sodium nitrite and sunset yellow and its effect on some biochemical parameters in young albino rats Eman G.E. Helal* and Mervat Abdel-Rahman***
Zoology Department, Faculty of Science, Al-Azhar University (Girls) ** Clinical Pathology Lab., Student Hospital, Cairo University, Giza Abstract Children usually
eat and drink food containing both food preservatives, as sodium nitrite and
food colourants, as sunset yellow (S.S.Y) at the same time. The mixture of the
two agents at the limited dose of each was found to be lethal. 1/10th
of this dose was used daily for 30 days. Animals were divided into three
groups. The first served as a control, while the second was orally
administered a mixture of sodium nitrite (NaNO3) and S.S.Y. The third received
garlic in addition to the above mixture. Half of the animals from each group
were decapitated after 30 days of treatment, while the other half was left for
another 15 days for recovery. Investigation of the mixture of sod.nitrite and
S.S.Y significantly decreases protein and albumin. Significant increases were
observed in cholesterol, gamma-glutamyltranspeptidase (GGT), alkaline
phosphatase (AP), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK).
No change was observed for Total protein, Triglyceride, aspartate
aminotransferase (AST), alanine aminotransferase(ALT) and acid phosphatase (AcP)
recorded. A complete recovery
from the abnormalities of most biochemical parameters was observed after the
recovery period or when garlic was administered. This draws attention to the
dangers of interactions of such preservatives and colourants. The present
study showed that even the permitted doses of colourants and food
preservatives may be harmful. And illustrate that usage of garlic may
ameliorate some of the expected hazards of food additions.
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