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Abstract |
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Effect Of Fractionated And Single Doses Gamma Irradiation On
Certain Mammalian Organs
Nabila A. R. Abdel Motaal* and Azza
Abdel Maguid**
*Radiation Biology and
** Radiation Health Research Departments, National Centre for Radiation
Research and Technology, Cairo, Egypt. Abstract
The present work aims to study the effect of fractionated and single
dose whole body gamma irradiation on the liver, spleen and intestine of albino
rats.
30 Male albino rats (100-120g) were used as experimental animals, they
were divided into three groups: The first group consists of 10 rats served as
control group (non irradiated), the second group (10 rats) were subjected to a
single dose of irradiation (5Gy) and the third group (10 rats) were subjected
to gamma of irradiation (5Gy) delivered at 5 successive exposures daily.
Histological results showed serious histopathological disorders in the
liver, spleen and intestine after exposure to the single dose of gamma
irradiation (5Gy), manifested by inflammation and infiltration with
mononuclear cells, haemorrhage, dilatation, congestion and widening of blood
vessels and necrosis of cells with pyknotic nuclei.
Exposure of rats to fractionated doses of whole body gamma irradiation
(1Gy) up to 5Gy resulted in less severe histopathological disorders in liver,
spleen and small intestine (jejunum),
This indicates the beneficial use of fractionated doses in planning for
radiotherapy in cancer patients, thus reducing the serious histopathological
changes of radiation on the human tissues. |
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