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Abstract |
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Cytogenetic and Developmental Effects of Antidepression
Drug (Cipralex) on Female Mice and Embryos Hanaa
M. Roshdy & Thanaa
M.T Shoman
Cell Biology
Department, Dokki,
Abstract
Escitalopram (cipralex®)
a new highly selective serotonin reuptake inhibitor, it is effective in the
treatment of patients with major depression. To evaluate the cytogenetics and developmental effects of cipralex throughout major organgenesis,
mice were administrated orally with a doses of 0.06,
0.12 and 0.24 mg/kg/day cipralex on gestation days
1-18 and examined on the 19th day of gestation for evidence of
maternal and fetal toxicity. Cipralex at different
doses tested produce significant toxic effects in reproductive parameters.
Significant embryo fetotoxic effects were observed
at tested dose levels as evidenced by total number of implantations, post.
Implantation loss and embryo malformations. There were increases in the
frequencies of micronuclei and chromosomal aberrations in both maternal and
embryonic cells treated with cipalex, these
increases were dose dependent. These results indicate that cipralex is considered to be cytogenetic
and embryo toxic drug when administered during pregnancy. Key words:- Escitalopram - chromosomal aberrations –
micronuclei – embryo – mice
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