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Abstract |
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Effect Of L-Cysteine On Blood Picture And Some Serum Parameters In Rats
Exposed To 2 Gauss Electro-Magnetic Field Mervat Abdel-Rahman Clinical pathology
laboratory, Student hospital, Abstract Objective: investigation of the bio-effects of exposure to 2
gauss electromagnetic field (EMF) on blood elements, blood glucose,
hepatocellular enzymes and bilirubin of mice and their possible modification
by L-cysteine. Methods: the following groups were studied; (1) normal rats
treated with saline; (2) normal rats treated with L-cysteine (18 mg/kg); (3)
rats exposed to EMF for 21 days and treated with the vehicle (saline) during
the exposure period; (4) rats exposed to EMF for 21 days and treated with
L-cysteine (18 mg/kg orally, 3 times per week) during the exposure period;
(5) rats exposed to EMF for 21 days and treated with the vehicle (saline)
during the exposure period and for 45 days after exposure; (6) rats exposed
to EMF for 21 days and treated with L-cysteine (18 mg/kg orally, 3 times per
week) during the exposure period and for 45 days after exposure; Results: in
rats exposed to low frequency EMF for 21 days (group2), marked increase in
aspartate aminotransferase (AST) and alanine aminotransferase (ALT)
activities in serum was observed. Plasma bilirubin level was raised.
Meanwhile, significant decrease in plasma glucose levels occured after
exposure to EMF. No significant changes were observed in haemoglobin level,
red blood cells or total leucocytic count noted in rats exposed to EMF. The elevations in serum bilirubin, AST and
ALT levels were reduced to near normal values in rats given L-cysteine druing
the 21 days of exposure (group3). On the other hand, in rats examined 45 days
after the end of the exposure period (group 3), no significant alterations
were noted as regards bilirubin, AST, ALT and glucose levels in serum. Conclusions: these results suggest that (1)
exposure to low frequency EMF of 50 Hz is associated with some degree of liver
injury reflected in increased leakage of hepatoceular enzymes into plasma as
well as an increase in serum bilirubin; (2) these alterations can be
ameliorated by the administration of L-cysteine, as well as; (3) by limiting
exposure to EMF. |
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