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Abstract |
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Effect of Systemic Lupus Erythematosus on some
Biochemical Parameters in Female Patients Eman G.E Helal*, Medhat El- Shafaey**, Hala Rahoma**
and Mervat Abdel- Rahman*** *Zoology Department, Faculty of Science, Abstract: It
has been noticed that there is an increase in the number of women suffering
from SLE. Most studies confirmed that serum DHEA (dehydroepiandrosterone) and
DHEA sulphate are lower among patients with SLE than among controls even-
during phases of inactive disease so we performed this study to detect the
level of DHEA-S in the female patients with SLE. The overall results confirm
that DHEA treatment was well- tolerated, significantly reduced the number of
SLE flares, and improved patient’s global assessment of disease activity.
Some serum parameters like liver and kidney functions were detected. Biochemical
analysis showed that there is a significant increase of total lipids,
cholestrol, triglycerides. But insignificant change in serum glucose, urea
nitrogen and uric acid levels were recorded. From the present study three
things were concluded. Firstly, there is a strong relationship between level
of DHEA and the progression of SLE. Secondly, liver activity and kidney
functions were not affected by SLE disease.Thirdly, DHEA treatment has a
beneficial effect on female patients. So this study recommended to follow up
DHEAS in female patients and use it in a proper dosage. In addition, further
study must be done. |
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