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Abstract |
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Mutagenic studies on the effect of Aldicarb “Temik”
and vitamin C as antioxidant agent on the white rat: (Chromosomal aberrations and Micronucleus tests) Fatma M. Hamam* and Ihab H. Foda*Department Of Mammalian Toxicology, Central Agricultural
Pesticides Laboratory, Agricultural Abstract
Widespread contamination of the environment due to increased and
frequently indiscriminate usage of insecticides during the last two decades
has aroused much concern over the possibility of their radiominetic effect.
Evidence accumulating over the years emphasized the indisputable link between
certain insecticides, chromosomal damage and possibility of gene mutation.
There is a wide variety of insecticides, among which the carbamates. Their
chemical relationship to ethyl carbamate makes them worthy of study for their
possible deleterious effect on biological system. The main object of the
present study is to evaluate the mutagenic effect of a carbamate insecticide”
Aldicarb” alone and in combination of vitamin C as an antioxidant agent to
decrease their mutagenicity. Male albino rats were tested orally for 48 hours , two doses of aldicarb were used in absence and in
the presence of viamin C (1/4 and 1/10) LD50. The obtained data showed highly
significant increase in the micronucleus (PCEM) and in chromosomal
aberrations in rat bone marrow cells at the two doses of aldicarb compared to
control group. (P< 0.0001). The
frequency of chromosomal aberrations and micronucleus decreased in rats
treated with aldicarb and vitamin C than in aldicarb treated group. From
these results we concluded that cytogenetic effect of aldicarb might be
decreased by the usage of vitamin as an antioxidant agent. |
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