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Abstract |
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Mitochondria and Nuclear changes in postimplanted mice
embryos After treatment with Cisplatim antitumour drugs Hassan M.El Ashmaoui
National Research center, Cell Biology Dept., Abstract
To evaluate a possible relationship of maternal exposure to
capsulation during postimp-lantation embryotoxicity, SWR pregnant female mice
were injected intraperitoneally on day 4 of gestation with 7mg/kg cisplatin
or with saline (0.4 ml) for the control group. Embryos were collected after
24h 48h, 72h, after injection. ultrastructural sections were used to
investigate the mitochondria and the nuclear changes Both the
mitochondria and the nuclei were damaged specially 48h and 72 h after
injection they may be related to cytotoxicity of the drug. Key words: platinum antitumour drugs, Mitochondria, Nucleus,
Mice embryos. |
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