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Change in eye color [Acquired heterochromia] - two cases are reported in which sympathectomy in adults resulted in ipsilateral Horner syndrome with heterochromia.

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1480396&dopt=Abstract

Ophthalmology. 1992 Dec;99(12):1815-7. Related Articles, Links  


Acquired heterochromia with horner syndrome in two adults.

Diesenhouse MC, Palay DA, Newman NJ, To K, Albert DM.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA.

BACKGROUND: Heterochromia iridis, asymmetry of iris pigmentation, has been well described with congenital Horner syndrome. Acquired heterochromia associated with lesions in the ocular sympathetic pathways in adulthood, however, is rare. METHODS: Two cases are reported in which sympathectomy in adults resulted in ipsilateral Horner syndrome with heterochromia. In each case, pharmacologic testing with cocaine and hydroxyamphetamine was performed. RESULTS: In both cases, sympathectomy occurred at the level of the second order neuron, but hydroxyamphetamine testing suggested at least partial third order neuron involvement. CONCLUSION: Acquired heterochromia can occur in adults. The partial response to hydroxyamphetamine in the two cases presented may reflect trans-synaptic degeneration of the postganglionic neuron. A reduction in trophic influences on iris melanocytes may have contributed to the observed heterochromia.

Publication Types: 
Case Reports

PMID: 1480396 [PubMed - indexed for MEDLINE] 

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