Benefits of alpha ketoanalogue

CKD is a serious problem prevalent almost worldwide, and without proper management, it leads to end-stage renal disease and threatens life. It is caused and complicated by increased blood pressure, prevalent high cholesterol, uncontrolled diabetes, kidney infections, and patients' regular long-term use of NSAIDs.

Nutritional management of CKD requires a balance between protein, phosphorus, sodium, potassium, and fluid with biochemical markers. 

Alpha ketoanalogue

Protein is an essential part of the human diet. Protein is composed of "building blocks" of the human body, also called amino acids. These amino acids are used for many important functions, such as making hormones in the human body to replenish the skin. 

•  When protein is broken down in our body into amino acids, you get waste by-products. The kidneys clear these. The main protein by-products that create problems for kidneys are nitrogen wastes. Because of the effect of nitrogenous wastes on the kidney and human body, doctors use modified protein intake as a nutrition therapy to support kidney health and slow the progression of kidney disease.

Alpha ketoanalogue comes underclass of nutritional supplement. It contains all the amino acids required inpatient with deficient protein metabolism. It improves renal function in patients with chronic renal disease with a glomerular filtration rate (GFR) less than 25 ml/min. Patients are advised to take a limited protein intake of 40 grams per day while receiving this medicine.

• . The Patient is advised to take a low protein diet and maintain a calorie routine while taking this supplement, leading to a delay in dialysis initiation and progression of kidney disease.
• It decreases the urea in the Patient's blood due to intake of non-essential amino acids.

Alpha Ketoanalalogue is also given in major surgeries of the heart. Always take alpha ketoanalogue with food to improve absorption

• Protein restriction may be helpful in patients with CKD, but for maintaining the balance between the amino acids and checking the improvement of eGFR, ketoanalogue is of miraculous importance.

Contents as per Alpha Ketoanalalogue manufacturers in India

• Calcium 2 Oxo 3 Phenyl propionate +Calcium 3 Methyl 2 Oxovalerate +Calcium 4 Methyl 2 Oxovalerate +Calcium+L Histidine +L Lysine +L Threonine +L Tryptophan +L Tyrosine

Uses of Alpha Ketoanalalogue

Chronic kidney disease

• It improves kidney function in chronic kidney disease patients by diminishing proteinuria, improving blood pressure levels, preserving eGFR>18ml/min, reducing hyperphosphatemia, decreasing Blood Urea Nitrogen, and hyperparathyroidism without causing malnutrition.

Diabetic nephropathy

• In patients with diabetes, it is helpful to combat diabetes as it reduces insulin resistance and improves glycemic value.

Blood pressure

• Ketoanalogues decrease systolic, and diastolic blood pressure in patients with CKD Patients are advised to take a low sodium diet.

Working as per Alpha Ketoanalalogue manufacturers in India

• As the nitrogen group is already removed from essential amino acids, alpha keto analogues are transaminated to essential by taking nitrogen from non-essential amino acids, decreasing the formation of urea because of the reusing of amino groups. Accumulation of toxins is reduced. 

• Ketoanalogues + Essential Amino Acids – it does not cause hyperfiltration of the residual nephrons, but it positively affects renal hyperphosphatemia and secondary hyperparathyroidism. 
• Moreover, renal osteodystrophy can also be improved. 
• The use of Amino Acid Ketoanalogue and a very low protein diet reduce nitrogen intake while preventing the harmful consequences of inadequate dietary protein intake. It maintains the same catabolic pathways as amino acids, but it works by improving the metabolism of protein in the body, thereby improving the renal function in kidney disease patients. 

Side effects of Alpha Ketoanalalogue

• Increased calcium levels in the blood
• Abdominal pain
• Vomiting
• Nausea
• Most of these side effects do not require medical attention as they will resolve gradually over some time. However, if the condition persists, you are advised to talk to your doctor.

• Patients should avoid consumption of alcohol while taking this medicine to reduce the unnecessary effects
• Pregnant women or breastfeeding women should consult a doctor before taking this medication.

Drug Interactions: 

Alpha Ketoanalogue may interact with various antibiotics (ciprofloxacin, tetracycline), an antineoplastic agent (estramustine).

Directions for Use

• It is best if taken along with a low-protein diet. Swallow tablet of Alpha ketoanalogue as a whole with a glass of water. Do not chew or break the tablet. Based on your medical situation, your doctor will decide for how long you need to take it.

Storage

• It should be stored in a cool and dry place away from sunlight

Warning

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be explained to the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Hypocalcemia

This medicine should be used with caution since it may increase the risk of increased calcium levels in the body. Reduce the intake of vitamin D and calcium sources if levels are high. Regular monitoring of the calcium levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Protein Intake

Patients are advised to take a limited protein intake of 40 grams per day while receiving this medicine.

Other medicines

Alpha Ketoanalogue may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines, including any herbs and supplements, before beginning treatment with this medicine.

Dosage

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.

Conclusion

Different research data has been analyzed that it decreases the mortality in patients with advanced diabetic kidney disease and chronic kidney disease. It prolongs the survival of pre-dialysis diabetic kidney disease. In patients with cardiovascular trauma, it decreases further complications. Hence the role of the ketoanalogue created by alpha ketoanalogue API manufacturer is of utmost importance in increasing the survival rate of patients with these vital organ dysregularities.