Unexpected scarcity of genes rekindles nature v. nurture debate
Does the finding that human beings have far fewer genes than
expected settle the nature v. nurture debate? Yes, say some
scientists. The scarcity of genes, they argue, means experience and
environment -- nurture -- must play a stronger role in shaping humans
than genes, or nature.
But other experts are equally vehement that the debate is far from
concluded.
The passions being raised recall the 1970s heyday of nature v.
nurture. Today as then, the debate often appears to be as much about
philosophy and politics as DNA.
In a recent New York Times article, Stephen Jay Gould, Harvard
zoologist and well-known writer, said the confirmation of only 30,000
to 40,000 human genes, instead of the predicted 140,000, undermines
geneticists' "central dogma": that one gene makes one
protein, and the sum of such proteins makes a person. He argued human
complexity cannot be generated by 30,000 genes and the lower number of
genes "marks the failure of reductionism" to explain
intricate biological systems. He suggested the finding will work to
liberate society from "simplistic and harmful" ideas
associated with genetic determinism.
But Steven Pinker, an evolutionary psychologist at the
Massachusetts Institute of Technology, says Mr. Gould exaggerates by
implying most scientists expected the genome project to uncover more
than 100,000 human genes.
Mr. Pinker had earlier estimated humans have about 50,000 genes
each, a figure he says is not radically out of sync with the 30,000 to
40,000 found in the genome study. Yet, even with fewer genes, he
claims, there is still substantial evidence humans have many innate
instincts and abilities, as well as built-in tendencies for
intelligence, aggression, shyness and other traits.
"No one can say whether 30,000 genes are too few, since no one
knows how many genes it would take to build a language instinct, or a
fear of snakes, or a moral sense," Mr. Pinker notes. "The
task is to figure out how that information is coded in the genome,
whether the number of genes is 30,000 or 75,000."
One theory holds that the large amount of non-genetic information
in the genome, so-called junk DNA (99% of our total DNA), plays an
important role in the control and timing of gene functioning. This
DNA, it is thought, could be a crucial cog in the cellular mechanisms
that differentiate a cat from a human. Another theory speculates that
human genes interact in a complex, not yet understood manner,
essentially multiplying their ability to carry out and control large
numbers of biological functions. Still another conjecture is that
scientists have simply miscounted.
Joseph LeDoux, professor of neuroscience at New York University,
believes Mr. Gould's attack on genetic causality to be timely and
justified. "Because of the abundance of genetic research being
done, the perception has been that everything is genetic," he
says.
Mr. LeDoux says evidence of fewer human genes weakens but does not
eliminate the argument for a genetic basis to human behaviour and
learning.
"Nature or nurture is a false dichotomy," he says.
"All learning is based on genetically based learning programs.
Experience however figures prominently in what we learn." He
claims environmental stimuli such as strong parental bonding or
malnutrition alter brain synapses, resulting in modified or learned
behaviour, a process called brain plasticity.
The contentious question at the centre of the nature or nurture
debate, however, is not whether genes or the environment both play a
role in human development, but precisely how much is a result of
genes, and how much due to experience. It is a question, to many
people, tinged with moral and political meaning.
Edward O. Wilson, a famous Harvard biologist, addressed this
question in his 1975 book Sociobiology. He estimated that as much as
50% of a person's personality traits, intelligence and behaviour could
be accounted for by genes. The book provoked vehement criticism. A
group called Science for the People said Mr. Wilson's theories
"provide a genetic justification of the status quo and existing
privileges for certain groups according to class, race and sex."
Mr. Wilson's book charged the modern "nature or nurture"
debate with as much political as scientific significance, leading
nurture advocates to take the side of the left, while nature backers
are seen to be more closely linked with views at the centre or right
of the political spectrum. For instance, while a nurture backer might
argue that crime can be eliminated only by reducing poverty, a nature
advocate might say decreasing crime requires better policing and
harsher penalties.
The legacy of this politicized version of the debate, Mr. Pinker
suggests, has led to many misconceptions about genetic-based models of
human development and behaviour. One of these, he says, is that genes
imply determinism.
"Genes are interested in propagating themselves, so they have
created a brain interested in sex," he says. "The brain can
override the genes by using a contraceptive. Without a contraceptive,
the agenda of the brain and genes coincide."