Associated Press
New York
— Pharmaceutical manufacturer Merck & Co. has begun a
small-scale human trial of a new experimental HIV vaccine, the
Wall Street Journal reported Thursday.
The vaccine has so far prevented AIDS in laboratory monkeys
that were injected with HIV strains that can sicken humans and
monkeys, the newspaper quoted sources as saying.
The vaccine did not stop the animals from contracting the HIV
virus, but their bodies have been able to control it, at least
for now, people familiar with the experiments told the
newspaper.
The company, based in Whitehouse Station, N.J., would not
discuss details of the laboratory trials, but said it began
testing the vaccine in healthy, uninfected volunteers last week.
The initial human trials are only to ensure that the vaccine
doesn't harm people, not to test whether it works.
Thirteen different AIDS vaccines are currently in clinical
trials, and some are farther along than the new Merck vaccine,
according to a recent survey of drug companies by Pharmaceutical
Research and Manufacturers of America, the industry trade group.
Two being developed by Wyeth-Lederle Vaccines, a division of
American Home Products of Madison, N.J., are being tested for
safety in people.
Sources familiar with Merck's research told the Journal that
its experimental vaccine combines a new vaccine with an older
one. It puts parts of HIV's genetic material directly into
people to stimulate immune cells called killer T-cells that
destroy cells infected by the virus, and it puts HIV genes into
a deactivated cold virus to greatly boost the number of killer
T-cells that go on the offensive.
Merck officials said they plan to present their findings at a
scientific forum in April. They already presented data to a
closed-door session with the National Institutes of Health
advisory committee on AIDS vaccine and another session with AIDS
activists, the newspaper said.
David Baltimore, Nobel-winning scientist who heads the NIH
committee, said, "After the presentation, members of the
committee were excited." He said he could not give details.
Some experts told the newspaper they worry the vaccine may
merely delay onset of AIDS. But even that could be a big
advance: A reduction in the virus level might reduce the chance
of a person transmitting it to others.
Worldwide, about 35 million people are living with HIV or
AIDS.
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