Several millennia passed, and a new threat rose against the mortal world from the demon kind. The devil Mundus, leading an army of demonic creations, dispatched his four most trusted lieutenants to prepare for him a gateway into the world of the humans on Miller Island. His plans to dominate the mortal dimension might have come to fruition, but he did not count on one element to come into play: Sparda begot a son by a mortal woman, the half-human half-demon Dante.
Having lost his mother and brother during an attack by demons several years prior, Dante established a private investigation firm specializing in hunting down and destroying supernatural creatures whenever they appear. The extermination services of the Devil May Cry detective agency can be purchased merely by uttering "the password", which can only be obtained through certain underground connections.
With the combined strength of his father's heritage and the weapons of the devils that were passed down to him, Dante reclaimed the powers buried within him and followed in his father's footsteps. Dante defeated Mundus and his devils, and sealed the breach between the mortal realm and the underworld.
Several years have passed. Dante is summoned by the Protectorate, a race of half-human, half-demon devil hunters such as himself, who have protected the ancient islands of Vidu Mali from the return of the devils that used to control the area. Flipping his trademark coin of Fate, Dante takes the assignment and sets off for Vidu Mali. His heritage is called upon once more to seal a rift between the worlds, forced by the demons that wish to enslave mankind.