Marshall Mathers - Jimmy
Kim Basinger - Stephanie
Mekhi Phifer - Future
Brittany Murphy - Alex
Evan Jones - Cheddar Bob
Omar Benson Miller - Sol George
De'Angelo Wilson - DJ Iz
Eugene Byrd - Wink
Taryn Manning - Janeane
Chloe Greenfield - Lily
Larry Hudson - Bouncer
Proof - Lil' Tic
Mike Bell - Shorty Mike
DJ Head - Battle DJ
Michael Shannon - Greg Buehl
Mary Hannigan - Mrs. Helgeland
Anthony Mackie - Papa Doc
Strike - Lyckety-Splyt
Nashawn "Ox" Breedlove - Lotto
Na'Keya Snoddy - Papa Doc's Girl
Malik Barnhardt - Moochie
Day Golfin - Day
Allen Adams - Omar
Hom - First Parking Lot Rapper
Obie Trice - Second Parking Lot Rapper
Njeri Earth - Third Parking Lot Rapper
Jennifer Kitchen - Willing Girl
Kyla Womack - Alex's Friend
Melissa Zaglanikzny - Christine
Rockey Black - Rocky
Craig Chandler - Paul
Paul Bates - Manny
Miz-Korona - Female Lunch Truck Rapper
Xzibit - Male Lunch Truck Rapper
Abdul Salaam El Razzac - Joe Lee Patton
Steven Monroe - Plant Worker
John Smith Jr. - Lobby Security Guard
Venicia Foreman - WJLB Receptionist
Waverly W. Alford II - Big O
Bushman - WJLB Disc Jockey
Adam Brook - Roy Darucher
