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| Owen Wilson | Marmaduke | |
| Emma Stone | Mazie | |
| George Lopez | Carlos | |
| Raugi Yu | Drama Trainer | |
| Christopher Mintz-Plasse | Giuseppe | |
| Steve Coogan | Raisin | |
| Stacy Ferguson | Jezebel | |
| Kiefer Sutherland | Bosco | |
| Marlon Wayans | Lightning | |
| Damon Wayans Jr. | Thunder | |
| Sam Elliott | Chupadogra | |
| Lee Pace | Phil Winslow | |
| Judy Greer | Debbie Winslow | |
| Caroline Sunshine | Barbara Winslow | |
| Finley Jacobsen | Brian Winslow |
| Director |
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| Producer | John Davis
Tariq Jalil |
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| Writer | Brad Anderson
Tim Rasmussen |
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| Cinematography | Greg Gardiner
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| Musician | Christopher Lennertz
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When Phil and Debbie Winslow relocate from their native Kansas to the sunny climes of Orange County, their big-hearted, havoc-wreaking Great Dane gets a taste of the dog's life, California-style. |
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