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| Rosanna Arquette | Roberta Glass | |
| Madonna | Susan | |
| Aidan Quinn | Dez | |
| Robert Joy | Jim | |
| Mark Blum | Gary Glass | |
| Laurie Metcalf | Leslie Glass | |
| Will Patton | Wayne Nolan | |
| John Turturro | Ray | |
| Anna Levine | Crystal |
| Director |
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| Producer | Michael Peyser
Sarah Pillsbury |
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| Writer | Leora Barish
Floyd Byars |
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Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline "Desperately Seeking Susan" proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan's life. |
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