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Ameloblastoma is a unique tumor in oral and maxillofacial region with various levels of proliferative activity in each type. The p53 is the most commonly found to be mutated in the human cancer and sometimes is overexpressed also in other lesions, such as ameloblastoma. Murine Double Minute 2 (MDM2) is able to physically associate with the p53 tumor suppressor and therefore block the growth suppressive functions by p53. In the present study, immunohistochemistry, western blotting and enzyme-linked immunosorbant assay for p53 mutant selective test were done. MDM2 was overexpressed in ameloblastoma and the counting results showed different numbers of MDM2 labeling index based on both WHO classification and cytological pattern. Basal ameloblastoma, which has a high proliferative activity, had the highest MDM2 labeling index. We suggested MDM2 protein caused the high proliferative activity of ameloblastoma, especially basal cell ameloblastoma. |
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