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Immunohistochemical evaluation of PCNA and Ki-67 in ameloblastoma |
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Thirty two ameloblastoma tissues were immunohistochemically studied by using monoclonal anti-PCNA and anti-Ki-67 antibodies. Positive cells were evaluated and analyzed in relation to the WHO classification, cytological pattern of the outer layer cell, clinical appearance, tumor’s location, radiographic appearance and patient’s age. In regard to the cytological pattern of the outer layer cells, the basal cell type had significantly higher PCNA (P<0.05) and Ki-67 (P<0.05) labelling indices than the cuboidal cell type. The solid type had significantly higher PCNA and Ki-67 labelling indices than the cystic and the mixed type. The labelling index of younger patient was found to be the lowest, the middle age was in the middle and the older patient was the highest. These results indicated that the proliferating activities of ameloblastomas are quite variable, and the evaluation of Ki-67 and PCNA seems to be good indicators to assess to the proliferating activity of each type of ameloblastoma. |
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Inumaru Restaurant, Fukuoka, Japan |
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My Favorite Links: |
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Yahoo! |
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Pubmed |
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Medical Dictionary |
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Time-Asia |
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My Info: |
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Name: |
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Ferry Sandra,DDS,PhD |
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[email protected] |
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