This little gray building at 16 N. Fredrick in Cape Girardeau, Missouri was at one time a hotbed of motorcoach activity!  Built in 1948 for St. Louis-Cape Bus Lines, Great Southern Coaches and Trailways.  Greyhound joining in 1968.  In it's day this station was open 24 hours and had about 50 arrivals and departures!  It closed in 1991 as a result of the Greyhound strike.
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