| agent | chemical name | syn | use /assay /comment |
| I-alkylating agents | are cpds capable of replace H in biological important material by alkyl gp | ||
| a-nitrogen mustards | adv :1-less toxic 2-more sol in water 3-no vesicant action | ||
| mechlorethamine HCl (Mustine HCl ,dichlorine HCl) | bis (B-chloroethyl) methylamine HCl | less toxic *assay : e alc KoH >3 ionized chlorine >volhard | |
| nitromin | |||
| chlorambucil ,leuteran ,C.B 134.8 | 4-[p-(n,n- bis -B chloro ethyl) amino] phenyl butyric acid | 1-chronic lymphocytic leuckemia 2-Hodgkin's disease (sarcoma of lymphoid structure) *assay e alc KOH >2cl >volhard | |
| Melphalan , Alkiran ,Sarcolysin {phenyl alanine mustard} | 3-(p-n,n bis (B-chloro ethyl) amino phenylalanine | *antimitotic in case of inoperable malignancies | |
| uracil mustard | |||
| Unamustine | 5-(n,n bis B chloroethyl amino uracil) | 1-Hidgkin's sisease 2-lymphocytic leuckemia & lymphocarcinoma | |
| Lomustine (CeeNu) | n-(B-chloroethyl)-n'-cyclohexyl n-nitroso urea | used as alkylating antineoplastic agent | |
| Endoxan (cytoxan ,cyclophosphamide) | 2-[n,n-bis B-chloro ethyl] -I-oxa-3-aza-2-oxo-3,4,5,6- tetrahydrophosphorin -2-amine | *inactive invitro *assay : | |
| Fosfamide (Isoendoxan ,isophosphamide ,Holoxan | N,3-Bis-B chloroethyl-3,4,5,6-tetrahydro -1-oxa-3-aza-2-oxo-phosphorin- 2 amine | *inoperable bronchial carcinoma 2-soft tissue carcinoma 3-breast cancer 4-ovarian cancer 5-testicular cancer 6-pancreatic carcinoma 7-malignant lymphamas | |
| b-ethylene imines (Aziridines) | |||
| Triethylenemelamine TEM | 2,4,6- Tris(aziridino)-s-triazine | taken orally | |
| phosphoramides TEPA & thio TEPA | triethylene phosphamide & triethylene thiophosphamides | ||
| Triaziquone (Trenimon) | 2,3,5- Tris -ethyleneimino -p-benzoquinone | ||
| c-Epoxides | |||
| Butane diepoxide | antitumour activity decrease as n. of methylene gp () epoxide gp increase from one to six | ||
| d-esters of sulphonic acids | |||
| Myleranlfan | 1,4-Bis (methylsulphonyloxy) butane | hyd e boiling water by heating under reflux >methanesulphonic acid is then tit # NaoH using ph ph | |