| agent | chemical name | syn | use/assay/comment |
| miscellaneous | |||
| urethane (ethyl carbamate) | *one of first organic cpd show anticancer activity*test of identity :hyd by acid or alkali *structure is very restrictive >any change abolish activity or less active | ||
| colchicine & demeclocine | colchicine R=COCH3 , Demeclocine R=CH3 | alkaloid isolated from plant colchicum autumnale *cholchicine :antimitotic ,demeclocine :myelocytic leukaemia **assay :alkaloidal assay | |
| cisplatin (Platinol ,platinex) | cis-dichlorodiammine platinum II | *used in combination e bleomycin & Vinblastine ** used in testicular tumour | |
| carboplatin (paraplatin) | 1,1-cyclobutane dicarboxylic acid platinum diammine complex | *str related to cisplatin e reduced nephrotoxicity *used in ttt of ovarian carcinoma & lung cancer | |
| Mitolactor (Dibromodulcitol) | 1,6-dibromo galactitol or 1,6-dibromo dulcitol | mech of action :alkylating agent | |
| Hydroxyurea (Hydrea ,hydroxycarbamide) | hydroxycarbamide | *mech :ribonucleotide reductase inhibitor ,inhibit DNA syn -*uses :melanoma ,chronic myelocytic leukemia ,inoperable carcinoma of ovary ,in combination of irradiation therapy for carcinomas of head & neck | |
| Dacarbazine (Deticene) | 5-(Dimethyltriazeno) imidazole-4-carboxamide | ||
| Procarbazine HCl (Natulan) | 4-(2-methyl hydrazinomethyl)-N-isopropyl benzamide | ||
| Tamoxifen citrate (Tamofen ,Nolvadex) | 1-(p-B-dimethylamino ethoxy phenyl) trans-1,2diphenyl -but-1-ene | used in ttt & prevention of breast cancer | |