| agent | chemical name | syn | use /assay /comment |
| 2-Antimetabolites | cpds e str closely related to the substance used for metabolism | ||
| a-folic acid antagonists | changes in 1-pteridine 2-PABA 3-glutamate 4-2,4 positions 5--9,10 positions 6-benzene ring substitution | ||
| `Diopterine & teropterine | petroyl -glutamyl - glutamyl glutamic acid | ||
| Aminopterin | 4-aminopteroyl glutamic acid ** p-(2,4-diamino-6-pteridinyl methylamino) benzoyl glutamic acid | ||
| Amethopterin (Methotrexate) (Lederle) | 10-methylaminopterin or 4-amino-10-methylpteroyl glutamic acid or p-(2,4-diamino-10methyl-6-pteridinylmethylamino) benzoyl glutamic acid | acute Leuckemia | |
| b-purine antagonists | ribose ,deoxyribose ,purine or pyrimidine >nucleoside >H3po4 >nucleotide >activation >nucleic acid | ||
| 6-mercaptopurine (purinethiol , Leukerin) | 6-mercaptopurine | test of impurity of hypoxanthine >spectrophotometrically ** antimetabolite of adenine *used in ttt of leuckemia | |
| thioguanine | 2-amino-6-mercaptopurine | ||
| 6-chloropurine | ttt of leuckemia | ||
| 8-azaguanine | 2-amino-6-hydroxy-8-azapurine | *all purine drv assayed by kjeldahl method *it is triazolo analogue of guanine | |
| c-pyrimidine antagonists | |||
| 5-flurouracil | *ttt of certain solid tumours for w surgery or irradiation is not possible * it interfere e syn of DNA | ||
| cytosine HCl (Anacytin) | 4-amino-2-hydroxypyrimidine HCl | *cytosine interfere e syn of nu a *test of identity : cytosine HCl + sod hypochlorite + 1 dp of amm hydroxide >red col | |
| Gemcitabine HCl (Gemzar) | 2'-deoxy-2',2'-difluorocytidine,1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose | *it is antimetabolite to cytosine *used in ttt of lung cancer ,pancreatic adenocarcinoma *mech :inhibition of DNA synthesis | |
| 3-Hormones | |||
| estrogens | post menopausal breast cancer & cancer of prostate | ||
| tostesterone | premenopausal breast cancer | ||
| corticosteroids > prednisone | used in some cancer esp Hodgkin's disease & leukemias | ||
| estramustine 17-phosphate (estracyt) | combination of N2 mustard with estradiol | ||