| disease | antibiotic | adverse effect |
| T.B | streptomycin (limited now) | 1-nephrotoxicity 2-ototoxicity 3-neuromuscular blokage (predisposing factors : myasthenia gravies ,severe hypocalcemia or concurrent admn of neuromuscular blocking agent |
| endocarditis | combin of PG or ampicillin e streptomycin | |
| Septicemia ,bone & joint infections | Gentamycin ,Tobramycin ,Netilmicin and Amikacin | |
| meningitis | ||
| urinary tract | ||
| pneumonia | ||
| endocarditis | ||
| renal diseases | Doxycyclin (long half life ,free from nephrotoxicity) | 1-nausia ,vomiting ,epigastric pain . 2-IV admn cause phlebitis 3-hepatotoxicity & nephrotoxicity 4-staining of teeth 5-retard bone growth 5-photo sensitivity 6-super infection |
| cholera | tetracyclines | |
| trachoma | ||
| acne | ||
| Meningitis caused by H.influenzae (& other infections) | chloram phenicol | 1-gray baby syndrome 2-Toxic bone marrow depression 3-aplastic anemia |
| Typhoid and para typhoid fever | ||
| topical treat of eye & ear infections | ||
| mycoplasma pneumonia infections | Macrolids | 1-mild gastro intestinal upset 2-rashes 3-choleastatic hepatitis 4-induce liver microsomal enzymes |
| coryne diphtheriae | ||
| gonorrhea & syphilis (2nd line ) | ||
| middle ear & sinus infections in children | ||
| toxoplasma gondii | Clarithromycin | |
| pelvic infections and urethritis cervicitis caused by chlamydia and gonococci | Azithromycin | |
| acute uncomplicated uninary tract inf | sulfonamides | 1-hyper sensitivity 2-haemolytic anemia 3-Kernicterus 4-crystal urea |
| Meningococal meningitis & shigellosis | ||
| strept infection e rheumatic fever in patients sensitive to penicillin | sulfadiazine & sulfisoxazole | |
| Melioidosis and infections caused by nocardia | trisulfapyridine (sulfadiazine ,sulfamerazine ,and sulfamethazine ) or trimethoprim- sulfamethoxazole or sulfisoxazole | |
| Trachoma | sulfa (tetracycline perefered) | |
| burning patients (ps. Aeruginosa) | topically active sulfonamides (silver sulfadiazine 1% cream) | |
| ocular infections | sulfacetamide | |
| urinary tract infections | Quinolones | 1-nausea, vomiting ,diarrhea 2-allergic reactions (rashes) 3-CNS effects (drowsiness) 4-sometimes :hemolytic anemia |
| intraabdominal and bilary infections | ciprofloxacin | |
| osteomyelitis | ||
| all forms of gonorrhea | ||
| pneumococcal pneumonia | penicillin G | 1-neurotoxicity (convulsion follow intrathecal injection rare) 2-superinfection (by candida albicans by using ampicillin ,amoxicillin or indanyl carbenicillin) 3-granulocytopenia (by methicillin and cloxacillin 4-large doses of Na & K salt from PG + bl level of these 2 cations so + danger in patients e renal insufficiency 5-hyper sensitivity |
| pneumococcal meningitis | ||
| anaerobic and microaerophilic bacteria (eg anaerobic brain and lung abscesses ,clostridia infect such as tetanus and gas gangrene | ||
| rheumatic fever (recurrent attacks) | Penzathine PG | |
| otitis media & chronic bronchitis | ampicillin & amoxacillin | |
| acute tonsilitis | oral PV ,severe attacks need parentral 10 days | |
| endocarditis | benzyl penicillin | |
| gonorrhea | penicillins | |
| syphilis | penicillins (essential treatment) | |
| typhoid fever | high doses of ampicillin | |
| urinary tract infect by E.coli & P.mitabilis | ampicillin & amdinocillin | |
| G-ve enteric bacteria w cause urinary ,respiratory ,billiary infections | Mezlocillin & piperacillin | |
| urinary ract infections ,both upper & lower resp tract infections | cephalosporins | 1-allergy reaction 2-nephrotoxicity (+ e diuretics eg furosemide or e nephrotoxic agent as gentamicin 3-super infection 4-Over bleeding (coagulation disorders ) in wide spectrum cephalosporins eg cefroperazone ,cefamandole and cefmenoxime |
| penicillin resistant gonorrhea | ||
| meningitis | ||