| Mefepristone |
steroidal
drug ,,orally active bind e
receptor of progesterone & glucocorticoids |
as
one oral dose , ineuropean countries as Abortificient followed by PGE2 & PGF2a to + its
effect |
1-nausia 2-headache 3-pain |
|
| Danazol |
weak progestational
androgenic activities ,bind to both a) Androgen & glucocorticoid , progesterone receptors *+ exc of progesterone in urine |
1-supression of ovary function 2- treat of endometriosis 3-treat of Hemophilia as stim of factor 8 |
1-wt gain 2-oedema
3-(-) breast size 4-fibrocystic brest 5-oily skin ,acne 6-headache |
|
| Androgens |
1-maturation of male genital organs & development 2ry sexual
characters a)growth of hair in pubic & axillary & face b) hypertropy of vocal cords >low pitch to voice 2-gradual develop. Of bone & closue of
epiphysis at puberty 3-+ RBCs production > treat .certain type of anemia
4-Anabolic action >+ muscle size ,muscle strength
5-activate sebaceous glands >acne *** androgen therapy in young age >premature closure
of epiphisis***exc in urine >androstene dione
(metabolite of testesterone) |
testosterone (short half
life) ,rapid metab in liver ,not taken orally 1-methyl
testosterone >oral & sublingual 2-tost. Propiolate >subling + I.M 3-fluoxy mesterone > oral *control sec by LH ,but FSH stimulate spermatogenisis |
1-replacement therapy in
testicular failure (Hypogonadism and Hypopituitarism) > treat. By GH followed by testost
after puberty 2-certain type of anemia to + RBCs production 3-treat of osteoporosis mainly in males 4-inhibit release or function of estrogen of endometriosis 5-+ muscle size & strength |
1-liver damage >esp tost
derivatives (methyl ,fluoxy mesterone ) 2-inhibit release of LH ,FSH >infertility 3-acne 4- musculanization in female |
testicular tissue 2-adrenal cortex 3-ovary |