II. Interactions between excision repair pathways in transcription coupled repair.

Nucleotide excision repair occurs by two pathways:

        A preferential pathway in which the template strand of genes that are being actively transcribed is preferentially repaired. Repair of the template strand is thought to occur as the DNA is being transcribed, using some of the components that make up the transcriptional machinery. This preferential repair pathway ensures that those genes of greatest importance to the cell, which are the genes the cell is actively transcribing, receive the highest priority on the “repair list”. A slower, less efficient pathway that corrects DNA strands in the remainder of the genome.