| DATE | OPPONENT | W/L | SCORE | WINNER | LOSER | SAVE | |
| 4/1 | @Anaheim | L | 1-4 | Finley | Pettitte | Percival | |
| 4/2 | @Anaheim | L | 2-10 | Hill | Wells | ||
| 4/3 | @Oakland | P | 0-0 | ||||
| 4/4 | @Oakland | L | 3-7 | Haynes | Cone | ||
| 4/5 | @Oakland | W | 9-7 | Nelson | Mohler | ||
| 4/6 | @Seattle | L | 0-8 | Moyer | Pettitte | ||
| 4/7 | @Seattle | W | 13-7 | Wells | Bullinger | ||
| 4/8 | @Seattle | W | 4-3 | Lloyd | Ayala | Stanton | |
| 4/10 | Oakland | W | 17-13 | Buddie | Dougherty | ||
| 4/11 | Oakland | W | 3-1 | Pettitte | Candiotti | Stanton | |
| 4/12 | Oakland | W | 7-5 | Buddie | Mathews | Stanton | |
| 4/13 | Anaheim | P | 0-0 | ||||
| 4/14 | Anaheim | P | 0-0 | ||||
| 4/15 | Anaheim | W | 6-3 | Wells | Hill | Nelson | |
| 4/17 | @Detroit | W | 11-2 | Pettitte | Thompson | ||
| 4/18 | @Detroit | W | 8-3 | Cone | Keagle | ||
| 4/19 | @Detroit | L | 1-2 | Moehler | Holmes | Jones | |
| 4/20 | @Toronto | W | 3-2 | Banks | Risley | Stanton | |
| 4/21 | @Toronto | W | 5-3 | Stanton | Plesac | ||
| 4/22 | @Toronto | W | 9-1 | Pettitte | Clemens | ||
| 4/24 | Detroit | W | 8-4 | Cone | Keagle | ||
| 4/25 | Detroit | W | 5-4 | Wells | Runyan | Rivera | |
| 4/26 | Detroit | P | 0-0 | ||||
| 4/27 | Toronto | W | 1-0 | Pettitte | Clemens | Rivera | |
| 4/28 | Toronto | L | 2-5 | Williams | Mendoza | Myers | |
| 4/29 | Seattle | W | 8-5 | Cone | Fassero | Rivera | |
| 4/30 | Seattle | W | 9-8 | Rivera | Ayala | ||
| 5/1 | @Kansas City | W | 2-1 | Irabu | Rapp | Rivera | |
| 5/2 | @Kansas City | W | 12-6 | Pettitte | Haney | ||
| 5/3 | @Kansas City | W | 10-1 | Mendoza | Belcher | ||
| 5/5 | @Texas | W | 7-2 | Cone | Burkett | ||
| 5/6 | @Texas | W | 15-13 | Stanton | Patterson | Rivera | |
| 5/8 | @Minnesota | W | 5-1 | Irabu | Radke | Nelson | |
| 5/9 | @Minnesota | L | 1-8 | Morgan | Pettitte | ||
| 5/10 | @Minnesota | W | 7-0 | Mendoza | Milton | ||
| 5/11 | Kansas City | P | 0-0 | ||||
| 5/12 | Kansas City | W | 3-2 | Wells | Rusch | Rivera | |
| 5/13 | Texas | W | 8-6 | Cone | Helling | Rivera | |
| 5/14 | Texas | L | 5-7 | Patterson | Banks | Wetteland | |
| 5/15 | Minnesota | L | 6-7 | Milton | Pettitte | Aguilera | |
| 5/16 | Minnesota | W | 5-2 | Mendoza | Tewksbury | Rivera | |
| 5/17 | Minnesota | W | 4-0 | Wells | Hawkins | ||
| 5/19 | Baltimore | W | 9-5 | Stanton | Charlton | ||
| 5/20 | Baltimore | W | 9-6 | Irabu | Key | ||
| 5/21 | Baltimore | W | 3-1 | Pettitte | Erickson | Rivera | |
| 5/22 | @Boston | L | 4-5 | Wakefield | Nelson | Gordon | |
| 5/23 | @Boston | W | 12-3 | Wells | Lowe | ||
| 5/24 | @Boston | W | 14-4 | Cone | Saberhagen | ||
| 5/25 | @Chi. White Sox | W | 12-0 | Irabu | Navarro | ||
| 5/26 | @Chi. White Sox | W | 7-5 | Nelson | Foulke | Rivera | |
| 5/27 | @Chi. White Sox | L | 9-12 | Simas | Nelson | Karchner | |
| 5/28 | Boston | W | 8-3 | Wells | Wakefield | Stanton | |
| 5/29 | Boston | W | 6-2 | Cone | Lowe | ||
| 5/30 | Boston | L | 2-3 | Saberhagen | Irabu | Gordon | |
| 5/31 | Boston | L | 7-13 | Martinez | Pettitte | ||
| 6/1 | Chi. White Sox | W | 5-4 | Nelson | Karchner | ||
| 6/2 | Chi. White Sox | W | 6-3 | Wells | Sirotka | Rivera | |
| 6/3 | Tampa Bay | W | 7-1 | Hernandez | Saunders | ||
| 6/4 | Tampa Bay | W | 6-1 | Irabu | Springer | ||
| 6/5 | Florida | W | 5-1 | Pettitte | Fontenot | ||
| 6/6 | Florida | W | 4-2 | Mendoza | Sanchez | Rivera | |
| 6/7 | Florida | W | 4-1 | Cone | Dempster | ||
| 6/9 | @Montreal | W | 11-1 | Hernandez | Perez | ||
| 6/10 | @Montreal | W | 6-2 | Irabu | Hermanson | ||
| 6/11 | @Montreal | L | 5-7 | Valdes | Nelson | Urbina | |
| 6/12 | Cleveland | P | 0-0 | ||||
| 6/13 | Cleveland | P | 0-0 | ||||
| 6/14 | Cleveland | W | 4-2 | Cone | Wright | Rivera | |
| 6/15 | @Baltimore | L | 4-7 | Erickson | Wells | Orosco | |
| 6/16 | @Baltimore | L | 0-2 | Ponson | Irabu | Rhodes | |
| 6/17 | @Baltimore | W | 5-3 | Pettitte | Mussina | Rivera | |
| 6/18 | @Cleveland | W | 5-2 | Nelson | Assenmacher | Rivera | |
| 6/19 | @Cleveland | L | 4-7 | Wright | Cone | Jackson | |
| 6/20 | @Cleveland | W | 5-3 | Wells | Burba | Rivera | |
| 6/21 | @Cleveland | L | 0-11 | Colon | Irabu | ||
| 6/22 | Atlanta | W | 6-4 | Nelson | Martinez | Rivera | |
| 6/23 | Atlanta | L | 2-7 | Glavine | Hernandez | ||
| 6/24 | @Atlanta | W | 10-6 | Cone | Millwood | Rivera | |
| 6/25 | @Atlanta | W | 6-0 | Wells | Neagle | ||
| 6/26 | @NY Mets | W | 8-4 | Mendoza | Leiter | Rivera | |
| 6/27 | @NY Mets | W | 7-2 | Pettitte | Jones | ||
| 6/28 | @NY Mets | L | 1-2 | Cook | Mendoza | ||
| 6/30 | Philadelphia | W | 9-2 | Cone | Loewer | ||
| 7/1 | Philadelphia | W | 5-2 | Wells | Beech | Rivera | |
| 7/2 | Philadelphia | W | 9-8 | Buddie | Spradlin | ||
| 7/3 | Baltimore | W | 3-2 | Pettitte | Orosco | ||
| 7/4 | Baltimore | W | 4-3 | Hernandez | Drabek | Rivera | |
| 7/5 | Baltimore | W | 1-0 | Cone | Erickson | Rivera | |
| 7/9 | @Tampa Bay | W | 2-0 | Pettitte | Rekar | Rivera | |
| 7/10 | @Tampa Bay | W | 8-4 | Irabu | Alvarez | Mendoza | |
| 7/11 | @Tampa Bay | W | 2-0 | Cone | Arrojo | Rivera | |
| 7/12 | @Tampa Bay | W | 9-2 | Stanton | Hernandez | ||
| 7/13 | @Cleveland | L | 1-4 | Wright | Hernandez | Jackson | |
| 7/14 | @Cleveland | W | 7-1 | Pettitte | Burba | ||
| 7/15 | @Detroit | W | 11-0 | Irabu | Greisinger | ||
| 7/16 | @Detroit | L | 1-3 | Moehler | Cone | Jones | |
| 7/17 | @Toronto | L | 6-9 | Clemens | Holmes | Myers | |
| 7/18 | @Toronto | W | 10-3 | Hernandez | Guzman | ||
| 7/19 | @Toronto | L | 3-9 | Williams | Pettitte | ||
| 7/20 | Detroit | L | 3-4 | Sager | Holmes | ||
| 7/20 | Detroit | W | 4-3 | Irabu | Florie | Rivera | |
| 7/21 | Detroit | W | 5-1 | Cone | Moehler | ||
| 7/22 | Detroit | W | 13-2 | Hernandez | Powell | Holmes | |
| 7/24 | Chi. White Sox | W | 5-4 | Pettitte | Ward | Rivera | |
| 7/25 | Chi. White Sox | L | 2-6 | Sirotka | Irabu | Simas | |
| 7/26 | Chi. White Sox | W | 6-3 | Wells | Navarro | Rivera | |
| 7/28 | @Anaheim | W | 9-3 | Cone | Dickson | ||
| 7/29 | @Anaheim | L | 5-10 | Sparks | Hernandez | ||
| 7/30 | @Anaheim | W | 3-0 | Mendoza | DeLucia | Rivera | |
| 7/31 | @Seattle | W | 5-3 | Irabu | Fassero | Rivera | |
| 8/1 | @Seattle | W | 5-2 | Wells | Moyer | ||
| 8/2 | @Seattle | L | 3-6 | Wells | Cone | Timlin | |
| 8/3 | @Oakland | W | 14-1 | Hernandez | Oquist | ||
| 8/4 | @Oakland | W | 10-4 | Mendoza | Witasick | Stanton | |
| 8/4 | @Oakland | W | 10-5 | Lloyd | Taylor | ||
| 8/5 | @Oakland | L | 1-3 | Candiotti | Irabu | ||
| 8/7 | Kansas City | W | 8-2 | Cone | Rapp | ||
| 8/7 | Kansas City | W | 14-2 | Wells | Haney | ||
| 8/8 | Kansas City | W | 14-1 | Hernandez | Rusch | ||
| 8/9 | Kansas City | W | 5-4 | Mendoza | Service | Rivera | |
| 8/10 | Minnesota | W | 7-3 | Irabu | Rodriguez | ||
| 8/11 | Minnesota | W | 7-0 | Wells | Milton | ||
| 8/12 | Minnesota | W | 11-2 | Cone | Hawkins | ||
| 8/13 | Texas | W | 2-0 | Hernandez | Helling | Rivera | |
| 8/14 | Texas | W | 6-4 | Pettitte | Sele | Rivera | |
| 8/15 | Texas | L | 5-16 | Stottlemyre | Irabu | ||
| 8/16 | Texas | W | 6-5 | Rivera | Hernandez | ||
| 8/17 | @Kansas City | W | 7-1 | Cone | Rosado | ||
| 8/18 | @Kansas City | W | 3-2 | Borowski | Whisenant | ||
| 8/19 | @Minnesota | L | 3-5 | Serafini | Pettitte | Aguilera | |
| 8/20 | @Minnesota | L | 4-9 | Rodriguez | Buddie | ||
| 8/21 | @Texas | W | 5-0 | Wells | Loaiza | ||
| 8/22 | @Texas | W | 12-9 | Bradley | Hernandez | Rivera | |
| 8/23 | @Texas | L | 10-12 | Helling | Hernandez | Wetteland | |
| 8/24 | Anaheim | L | 3-7 | McDowell | Pettitte | ||
| 8/25 | Anaheim | L | 6-7 | Watson | Stanton | Percival | |
| 8/26 | Anaheim | L | 4-6 | Juden | Bradley | Percival | |
| 8/26 | Anaheim | W | 7-6 | Rivera | Fetters | ||
| 8/27 | Anaheim | W | 6-5 | Tessmer | Fetters | ||
| 8/28 | Seattle | W | 10-3 | Hernandez | Spoljaric | ||
| 8/29 | Seattle | W | 11-6 | Pettitte | Cloude | ||
| 8/30 | Seattle | L | 3-13 | Swift | Irabu | ||
| 9/1 | Oakland | W | 7-0 | Wells | Candiotti | ||
| 9/2 | Oakland | L | 0-2 | Heredia | Cone | Taylor | |
| 9/4 | @Chi. White Sox | W | 11-6 | Lloyd | Bradford | ||
| 9/5 | @Chi. White Sox | L | 5-9 | Abbott | Pettitte | ||
| 9/6 | @Chi. White Sox | L | 5-6 | Baldwin | Irabu | Howry | |
| 9/7 | @Boston | L | 3-4 | Swindell | Wells | Gordon | |
| 9/8 | @Boston | W | 3-2 | Cone | Martinez | Rivera | |
| 9/9 | @Boston | W | 7-5 | Mendoza | Wakefield | Rivera | |
| 9/10 | Toronto | W | 8-5 | Pettitte | Hentgen | Holmes | |
| 9/11 | Toronto | L | 4-5 | Almanzar | Irabu | Person | |
| 9/12 | Toronto | L | 3-5 | Carpenter | Wells | Person | |
| 9/13 | Toronto | L | 3-5 | Escobar | Cone | Person | |
| 9/14 | Boston | W | 3-0 | Hernandez | Martinez | ||
| 9/15 | Boston | L | 4-9 | Wakefield | Jerzembeck | ||
| 9/16 | @Tampa Bay | L | 0-7 | Saunders | Pettitte | ||
| 9/17 | @Tampa Bay | W | 4-0 | Irabu | Santana | ||
| 9/18 | @Baltimore | W | 15-5 | Wells | Guzman | ||
| 9/19 | @Baltimore | L | 3-5 | Ponson | Cone | Mills | |
| 9/20 | @Baltimore | W | 5-4 | Hernandez | Johns | Rivera | |
| 9/21 | Cleveland | L | 1-4 | Nagy | Pettitte | Shuey | |
| 9/22 | Cleveland | W | 10-4 | Mendoza | Burba | ||
| 9/22 | Cleveland | W | 5-1 | Irabu | Ogea | ||
| 9/23 | Cleveland | W | 8-4 | Bradley | Jacome | ||
| 9/24 | Tampa Bay | W | 5-2 | Buddie | Alvarez | Nelson | |
| 9/25 | Tampa Bay | W | 6-1 | Hernandez | Eiland | ||
| 9/26 | Tampa Bay | W | 3-1 | Cone | Wade | ||
| 9/27 | Tampa Bay | W | 8-3 | Bruske | White | ||
| 9/29 | Texas | W | 2-0 | ||||
| 9/30 | Texas | W | 3-1 | ||||
| 10/2 | @Texas | W | 4-0 | ||||
| 10/6 | Cleveland | W | 7-2 | ||||
| 10/7 | Cleveland | L | 1-4 | ||||
| 10/9 | @Cleveland | L | 1-6 | ||||
| 10/10 | @Cleveland | W | 4-0 | ||||
| 10/11 | @Cleveland | W | 5-3 | ||||
| 10/13 | Cleveland | W | 9-5 | ||||
| 10/17 | San Diego | W | 9-6 | ||||
| 10/18 | San Diego | W | 9-3 | ||||
| 10/20 | @San Diego | W | 5-4 | ||||
| 10/21 | @San Diego | W | 3-0 |