| Transactions | ||||
| No. | Team | Released | Acquired | Left |
| Week 1 | ||||
| 1 | Woglom's Warriors | Jeff Garcia (TB) | Matt Cassel (NE) | 9 |
| Week 2 | ||||
| 2 | Woglom's Warriors | Colston, Marques (NO) {IR} | Randle-El, Antwaan (Was) | 8 |
| 3 | Hell's Angelas | Walker, Javon (Oak) {IR} | Royal, Eddie (Den) | 9 |
| 4 | Hooters | Brady, Tom (NE) {IR} | Warner, Kurt (Arz) | 9 |
| 5 | Hooters | Young, Vince (Ten) {IR} | Flacco, Joe (Bal) | 8 |
| 6 | Woglom's Warriors | Watson, Ben (NE) {IR} | Scheffler, Tony (Den) | 7 |
| Week 3 | ||||
| 7 | Hell's Angelas | Mendenhall, Rashard (Pit) | Pittman, Michael (Den) | 8 |
| 8 | Hell's Angelas | Gramatica, Martin (NO) | Prater, Matt (Den) | 7 |
| 9 | Woglom's Warriors | Galloway, Joey (TB) {IR} | Bryant, Antonio (TB) | 6 |
| 10 | Glazed Donuts | Hall, Andre (Den) | Jones, Felix (Dal) | 9 |
| 11 | Hooters | Lewis, Marcedes (Jac) | Toomer, Amani (NYG) | 7 |
| Week 4 | ||||
| 12 | Woglom's Warriors | Ginn, Ted (Mia) | Fasano, Anthony (Mia) | 5 |
| 13 | Woglom's Warriors | Pope, Leonard (Arz) | Hilliard, Ike (TB) | 4 |
| 14 | Woglom's Warriors | White, Roddy (Atl) | Lloyd, Brandon (Chi) | 3 |
| 15 | Headbutts | Westbrook, Brian (Phi) {IR} | Buckhalter, Correll (Phi) | 9 |
| 16 | Hell's Angelas | Anderson, Derek (Cle) | O'Sullivan, J.T. (SF) | 6 |
| 17 | Benchwarmers | Shockey, Jeremy (NO) {IR} | White, Roddy (Atl) | 9 |
| 18 | Glazed Donuts | Parker, Willie (Pit) {IR} | Johnson, Chris (Ten) | 8 |
| 19 | Hoochie Mommy | Green, Ahman (Hou) | Slaton, Steve (Hou) | 9 |
| 20 | Geeks on Call | Bulger, Marc (StL) | Edwards, Trent (Buf) | 9 |
| 21 | Flounders | Nugent, Mike (NYJ) | Mare, Olinde (Sea) | 9 |
| 22 | Flounders | Burleson, Nate (Sea) {IR} | Hardy, James (Buf) | 8 |
| Free | Hell's Angelas | Hardy, James (Buf) | Walker, Javon (Oak) {IR} | Free |
| Free | Woglom's Warriors | Watson, Ben (NE) {IR} | none | Free |
| Week 5 | ||||
| 23 | Hell's Angelas | Pittman, Michael (TB) | McClain, LeRon (Bal) | 5 |
| 24 | Hoochie Mommy | Palmer, Carson (Cin) | Orton, Kyle (Chi) | 8 |
| 25 | Glazed Donuts | Boldin, Anquan (Arz) {IR} | Moore, Lance (NO) | 7 |
| 26 | Headbutts | Williamson, Troy (Jac) | Walter, Kevin (Hou) | 8 |
| Free | Headbutts | Smith, Kevin (Det) | Westbrook, Brian (Phi) {IR} | Free |
| Week 6 | ||||
| 27 | Hell's Angelas | Walker, Javon (Oak) | Bruce, Isaac (SF) | 4 |
| 28 | Benchwarmers | Young, Selvin (Den) | Hightower, Tim (Arz) | 8 |
| 29 | Woglom's Warriors | Cassel, Matt (NE) | Campbell, Jason (Was) | 2 |
| 30 | Headbutts | Curtis, Kevin (Phi) {IR} | Stuckey, Chansi (NYJ) | 7 |
| 31 | Geeks on Call | Hasselbeck, Matt (Sea) | Pennington, Chad (Mia) | 8 |
| Week 7 | ||||
| 32 | Hell's Angelas | McClain, LeRon (Bal) | Rhodes, Dominic (Ind) | 3 |
| 33 | Hell's Angelas | O'Sullivan, J.T. (SF) | Johnson, Brad (Dal) | 2 |
| 34 | Hooters | Flacco, Joe (Bal) | Collins, Kerry (Ten) | 6 |
| 35 | Geeks on Call | Taylor, Fred (Jac) | Morris, Sammy (NE) | 7 |
| 36 | Glazed Donuts | Jones, Felix (Dal) {IR} | McClain, LeRon (Bal) | 6 |
| 37 | Hoochie Mommy | Addai, Joseph (Ind) {IR} | Moore, Mewelde (Pit) | 7 |
| Free | Glazed Donuts | Smith, L.J. (Phi) | Boldin, Anquan (Arz) {IR} | Free |
| Week 8 | ||||
| 38 | Hooters | Collins, Kerry (Ten) | Ryan, Matt (Atl) | 5 |
| 39 | Hooters | Bush, Reggie (NO) {IR} | Smith, Kevin (Det) | 4 |
| 40 | Hell's Angelas | Winslow, Kellen (Cle) | Avery, Donnie (StL) | 1 |
| 41 | Hell's Angelas | Bowe, Dwayne (KC) | Walker, Javon (Oak) | 0 |
| 42 | Hell's Angelas | Crosby, Mason (GB) | Elam, Jason (Atl) | -1 |
| 43 | Glazed Donuts | Romo, Tony (Dal) {IR} | O'Sullivan, J.T. (SF) | 5 |
| 44 | Glazed Donuts | Chambers, Chris (SD) {IR} | Smith, L.J. (Phi) | 4 |
| 45 | Glazed Donuts | Mauroney, Laurence (NE) | Thomas, Pierre (NO) | 3 |
| Free | Woglom's Warriors | Lloyd, Brandon (Chi) | Colston, Marques (NO) {IR} | Free |
| Free | Benchwarmers | Shockey, Jeremy (NO) {IR} | none | Free |
| Week 9 | ||||
| 46 | Woglom's Warriors | Perry, Chris (Cin) | Green-Ellis, Benjarvis (NE) | 1 |
| 47 | Woglom's Warriors | Hilliard, Ike (TB) | Henderson, Devery (NO) | 0 |
| Free | Woglom's Warriors | Galloway, Joey (TB) {IR} | none | Free |
| 48 | Geeks on Call | Morris, Sammy (NE) {IR} | Faulk, Kevin (NE) | 6 |
| Free | Glazed Donuts | Thomas, Pierre (NO) | Parker, Wille (Pit) {IR} | Free |
| Free | Headbutts | Stuckey, Chansi (NYJ) | Curtis, Kevin (Phi) {IR} | Free |
| Free | Glazed Donuts | Hester, Devin (Chi) | Chambers, Chris (SD) {IR} | Free |
| 48 | Glazed Donuts | O'Sullivan, J.T. (SF) | Bulger, Marc (StL) | 2 |
| 49 | Glazed Donuts | Smith, L.J. (Phi) {IR} | Washington, Nate (Pit) | 1 |
| 50 | Hoochie Mommy | Johnson, Larry (KC) {IR} | Addai, Joseph (Ind) {IR} | 6 |
| Week 10 | ||||
| 51 | Geeks on Call | Seattle Seahawks | Arizona Cardinals | 5 |
| 52 | Benchwarmers | McGahee, Willis (Bal) {IR} | Rice, Ray (Bal) | 7 |
| 53 | Benchwarmers | McFadden, Darren (Oak) | Torain, Ryan (Den) | 6 |
| Week 11 | ||||
| 54 | Hoochie Mommy | Rice, Sidney (Min) | Bowe, Dwayne (KC) | 5 |
| 55 | Headbutts | Miller, Heath (Pit) | Boss, Kevin (NYG) | 6 |
| Free | Hoochie Mommy | Moore, Mewelde (Pit) | Johnson, Larry (KC) {IR} | Free |
| Free | Benchwarmers | Rice, Ray (Bal) | McGahee, Willis (Bal) {IR} | Free |
| McGahee, Willis (Bal) | Forte, Matt (Chi) | |||
| 56 | Benchwarmers | White, Roddy (Atl) | Scheffler, Tony (Den) | 5 |
| Berrian, Bernard (Min) | Colston, Marques (NO) | |||
| Forte, Matt (Chi) | McGahee, Willis (Bal) | |||
| 57 | Woglom's Warriors | Scheffler, Tony (Den) | White, Roddy (Atl) | -1 |
| Colston, Marques (NO) | Berrian, Bernard (Min) | |||
| Week 12 | ||||
| 58 | Headbutts | Buckhalter, Correll (Phi) | Askew, B.J. (TB) | 5 |
| 59 | Hell's Angelas | Prater, Matt (Den) | Carney, John (NYG) | -2 |
| 60 | Hell's Angelas | Johnson, Brad (Dal) | Thigpen, Tyler (KC) | -3 |
| 61 | Hell's Angelas | Rhodes, Dominic (Ind) | Dunn, Warrick (TB0 | -4 |
| 62 | Hell's Angelas | Carney, John (NYG) | Crosby, Mason (GB) | -5 |
| Free | Geeks on Call | Faulk, Kevin (NE) | Morris, Sammy (NE) {IR} | Free |
| Week 13 | ||||
| 63 | Benchwarmers | Garrard, David (Jac) | Cassel, Matt (NE) | 4 |
| 64 | Woglom's Warriors | McGahee, Willis (Bal) | Thomas, Pierre (NO) | -2 |
| Free | Glazed Donuts | Smith, L.J. (Phi) {IR} | Free | |
| Week 14 | ||||
| 65 | Benchwarmers | Barber, Marion (Dal) {IR} | Choice, Tashard (Dal) | 3 |
| Week 15 | ||||
| 66 | Benchwarmers | Hillis, Peyton (Den) | Ward, Derrick (NYG) | 2 |
| 67 | Headbutts | Johnson, Rudi (Det) | Washington, Leon (NYJ) | 4 |
| 68 | Glazed Donuts | Jacobs, Brandon (NYG) {IR} | Moore, Mewelde (Pit) | 0 |
| Week 15 | ||||
| Free | Glazed Donuts | Parker, Willie (Pit) | Jacobs, Brandon (NYG) {IR} | Free |