Fencing
Fencing isn't a big factor for the maned wolf unless you have one at a zoo. It needs an open environment, but if you have to put up a fence, put one up but give them plenty of room to roam around.
Handling
You don't really handle a maned-wolf. You can watch it and take care of it at a zoo or preservation area since it is an endangered species. As far as handling, if you really got close to a maned-wolf, he would probably rip you into two.
You have to take care of maned-wolves now because they are endangered. You must take care of them. They are strong runners and hunt very well.
Diet
Maned-wolves can eat just about anything if they are hungry enough. If you get too close, they may be so hungry as to try to eat a human. Be careful around them. They are other carnivores and they like good meat.