(Special side effects of chemotherapeutic agents)| Medication | Side Effect |
Picture |
|
(A) Adriamycin (Doxorubicin) |
Cardio-toxicity Irreversible, dose-dependent |
|
| (B) Bleomycine |
Pulmonary toxicity Progress from rales, to cough, to fibrosis |
|
| (C) Cis-platin |
Oto-toxicity High-frequency hearing loss and tinnitus Nephro-toxicity Dose-related toxicity of the distal convoluted tubule and collecting duct; Ameliorate by aggressive hydration and diuresis |
|
| (M) Methotrexate |
Stomatitis/Mucositis Ulcers of the mouth Myelosuppression |
|
| (O) Cycl-O-Phosphamide |
Hemmorrhagic cystitis Acrolein, a metabolite of the drug in the urine, causes cystitis. Hydration & IV MESNA (sodium-2-mercaptoethane sulfonate) minimizes problem |
|
| (V) Vincristine |
Paresthesias of extremities Loss of reflexes Foot drop Ataxia Cellulitis Phlebitis |
