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• HEADACHE:
• MIGRAINE HEADACHE: Often preceded by aura, and associated with weakness, numbness, and paresthesias.
• TENSION HEADACHE: Usually is frontal or occipital. Tends to be recurrent.
• CLUSTER HEADACHE: In males, occurring at night, 2-3 hours after falling asleep. Symptoms are intense unilateral orbital pain (over one eye), with lacrimation, rhinorrhea, flushing. Usually lasts about 1 hour.
• CAUSES of SECONDARY HEADACHE:
• Meningismus: Stiff neck. If it occurs with the "worst headache of my life," then you should be suspicious of subarachnoid hemorrhage.
• Projectile Vomiting: Headache with projectile vomiting, occurring in morning, usually means increased intracranial pressure.
• Transient loss of Consciousness: Headache accompanied by transient loss of consciousness should raise question of stroke.
• SYNCOPE and LOSS of CONSCIOUSNESS:
• SEIZURES:
• Types of Seizures:
• Complex Partial Seizures: Patients commonly have feelings of fear or deja vu associated with complex partial seizures.
• Grand Mal Seizures: Tonic-clonic, often with loss of autonomic control.
• Petit Mal Seizures: Lasting for a short period of time -- only a few seconds.
• CAUSES of SEIZURE:
• Adolescents (12-20): Idiopathic (Epilepsy), Trauma, Drug and alcohol withdrawal
• Young Adults (20-35): Trauma, alcoholism, brain tumor
• Older adults (35+): brain tumor, CVA, metabolic disorders, electrolyte imbalances (hyponatremia, hypoglycemia, uremia).
• CHANGES in VISION:
• Amaurosis Fugax: Transient, painless loss of vision in one eye, due to ischemic changes in retina. Usually due to carotid artery stenosis or some form of retinal artery occlusion.
• Other symptoms, such as weakness, paresthesias, often accompany the Amaurosis Fugax.
• Retrobulbar Neuritis: Occurs in Multiple Sclerosis and may cause transient loss of vision in one eye.
• CHANGES in HEARING:
• CHANGES in SPEECH:
• Dysarthria: Difficulty in articulating words.
• Dysphonia: Difficulty speaking due to impaired phonation ability.
• Aphasia: Inability to produce (motor aphasia) or understand (receptive aphasia) meaningful speech.
• PARALYSIS or WEAKNESS: Paresis is intermittent weakness.
• CAUSES of Paresis:
• Myasthenia Gravis (fatigable weakness)
• Hypokalemia can result in periodic paralysis.
• Transient ischemic attacks (TIA's): Recurrent Transient weaknesses in an upper extremity, accompanied by numbness and paresthesia.
• Peripheral neuropathies
• Polymyositis or dermatomyositis.
• NUMBNESS and PARESTHESIA:
• Hypocalcemia, hypomagnesemia
• Hyperventilation syndrome
• Paraneoplastic syndrome.
• Medications: isoniazid, metronidazole.
• CHANGES in MOOD and SLEEP PATTERN:
• ALCOHOL and DRUG USE, SEXUAL HISTORY:
• Sexual history: In the neuro exam, may inquire about it to evaluate risk of HIV encephalopathy.
• Alcoholism manifests a lot of neurological symptoms (Wernicke, beriberi, peripheral neuropathies).

NEUROLOGIC EXAM:

• ASSESSMENT of MOTOR FUNCTION: Sometimes pluses and minuses can be used for even finer grading.
• 0: No contraction; paralysis
• 1: Trace of contraction.
• 2: Moves if gravity is eliminated.
• 3: Moves against gravity.
• 4: Moves against gravity and against some resistance.
• 5: Normal strength.
• Motor Abnormalities:
• Hysteria: To test whether weakness in the leg is from hysteria or is organic, put a hand on both limbs and have the patient lift one limb against the hand's resistance.
• If the cause of motor weakness is organic, then examiner should feel the other leg move the opposite direction in compensation.
• If it is hysteria, then the other leg remains still.
• Fasciculations: Twitchings in resting muscles. May be normal if they are occasional or precipitated by cold. They may be a sign of Amyotrophic Lateral Sclerosis (ALS) if they are accompanied by weakness.
• Tics: Normal movements of muscle groups (such as winking or grinning) occurring involuntarily, as in Tourette's Syndrome.
• Tetany: Involuntary muscle spasms.
• Causes: Tetanus, hypocalcemia, hypomagnesemia, hyperventilation syndrome.
• Chvostek's Sign: Tap over facial nerve anterior to ear, and look for contraction of the facial muscles, especially shutting of eyes.
• Trousseau's Phenomenon: Inflate a blood-pressure cuff to systolic pressure and maintain for 1-2 minutes. Induction of carpal-pedal spasm indicates latent tetany.
• Tremors: Oscillating movements caused by involuntary contractions of muscle groups.
• SENSORY EVALUATION
• Peripheral Neuropathies tend to occur in hand-and-glove distribution -- at the distal ends of the extremities.
• PAIN: Upon pinprick, patient may experience hypalgesia (reduced pain), hyperalgesia, or analgesia (no pain).
• LIGHT TOUCH:
• Hypesthesia = Impaired light touch sensation. Also related to light-touch are hyperesthesia, paresthesia, and anesthesia (no light touch).
• Sensory Extinction: In parietal lobe lesions, if you put a pinprick on both sides of the body of a patient simultaneously, the patient will not perceive the prick on the affected side of the lesion. If the pins are placed sequentially, then the patient still retains normal sensation on both sides.
• STEREOGNOSIS: Being able to identify objects with your eyes closed.
• CEREBELLAR FUNCTION:
• Dysergia: Improper coordinated function of a muscle group.
• Dysmetria: Inability to properly guage the distance between two points. Tested with finger-to-nose movements.
• Dysdiadochokinesia: Inability to do rapid alternating movements.
• Scanning Speech: Prolonged separation of syllables, often seen with cerebellar dysfunction.
• GAIT Disturbances:
• Cerebellar Lesions: Central cerebellar lesion shows unsteady gait, but conventional cerebellar signs may be normal.
• Posterior Columns Lesions: Loss of proprioception results in unsteady gait when eyes are closed, but relatively normal gait when eyes are open.
• Festinating Gait: Parkinsonian gait, shuffling walk.
• Romberg Test: Patient can't maintain balance with legs tight together, with eyes closed.
• Titubation: Body tremor when standing or walking, sign of cerebellar disease.

REFLEXES:

• Deep Tendon Reflexes:
• Upper Extremity:
• Biceps Reflex: Elbow flexion.
• Triceps Reflex: Forearm extension.
• Brachioradialis Reflex: Tap distal radius ------> flexion and partial supination of the forearm.
• Lower Extremity:
• Patellar Reflex: Contraction of Quadriceps (strongest muscles in body) and extension of leg.
• Suprapatellar Reflex: Above the knee; same response.
• Achilles Reflex: Causes plantarflexion of foot.
• Reflex grading:
• 0: Complete absence
• 1: Diminished
• 2: Normal Reflex
• 3: Hyperactive reflex
• 4: Clonus
• Superficial Reflexes:
• Upper Abdominal: Ipsilateral contraction of abdominal muscles on the stroked side.
• Lower Abdominal: Ipsilateral contraction of abdominal muscles on the stroked side.
• Cremasteric: Stroke inner thigh ------> elevation of testes.
• Brainstem Reflexes:
• Corneal Reflex
• Pupillary Light Reflex
• Gag Reflex
• Abnormal Reflexes:
• Babinski Sign: Stroke bottom of the foot ------> fanning (eversion) of big toe.
• Chaddock's Reflex: When the external malleolar skin area is irritated, extension of the great toe occurs in cases of organic disease of the corticospinal reflex paths.
• Oppenheim's Sign: Scratch inner side of leg ------> extension of toes. Sign of cerebral irritation.
• Gordon's Sign: Squeeze the calf muscles and note the response of the great toe. Fanning or extension is considered abnormal.
• Hoffman's Sign: Flexion of the terminal phalanx of the thumb and of the second and third phalanges of one or more of the fingers when the volar surface of the terminal phalanx of the fingers is flicked.
• It is significant for pyramidal tract disease when it is unilateral. If it is bilateral than the meaning is uncertain.
• Absence of Superficial Reflexes: Unilateral suppression of superficial reflexes often results from upper motor lesions subsequent to a CVA.
• Primitive Reflexes: Presence of primitive reflexes is often a sign of frontal lobe lesions.
• Suck Reflex: Gently tap or rub the upper lift ------> elicit a reflexive sucking or puckering response.
• Grasp Reflex: Stroke the patient's palm, causing him to grasp your fingers. A positive test occurs when the patient does not let go of your fingers.
• Palmomental Sign: Rub the thenar eminence ------> elicit reflexive contraction of the muscles of the chin.

CRANIAL NERVE EVALUATION:

• CN I: OLFACTORY
• TEST: Have patient identify objects by smell.
• ABNORMAL:
• Head trauma with fracture of cribriform plate
• Neoplasm in anterior fossa: meningioma
• CN II: OPTIC
• TEST: Visual acuity, funduscopic exam
• ABNORMAL: Lots of causes of blindness
• CN III: OCULOMOTOR
• TEST:
• Have patient move eyes through all fields of vision. Intact 3^rd nerve means that eyes can move medially, superiorly, and inferiorly.
• Pupillary Reflex: Check for pupillary response to light in same eye and contralateral eye.
• Ptosis: Ptosis may occur due to 3^rd nerve palsy.
• ABNORMAL:
• Unilateral CN-III Palsy: Subarachnoid hemorrhage resulting from aneurysm, diabetes, atherosclerosis.
• Horner's Syndrome: Usually occurs from bronchogenic carcinoma (Pancoast Tumor) impinging on the Superior Cervical Ganglion.
• CN IV: TROCHLEAR
• TEST:
• ABNORMAL:
• CN V: TRIGEMINAL
• TEST:
• Sensory: Check corneal reflex. Test facial sensation with eyes closed.
• Motor: Have patient clench teeth and palpate masseter muscle.
• ABNORMAL:
• Lost Corneal Reflex: Tumor of the cerebellopontine angle.
• Tic Douloureux: Irritative lesions of the CN V sensory roots.
• Spasm of muscles of mastication: tetanus, adverse reaction to Phenothiazines.
• CN VI: ABDUCENS
• TEST: Look laterally.
• ABNORMAL:
• Diabetes, atherosclerosis, increased ICP, neoplasm.
• CN VII: FACIAL
• TEST: Have patient smile, blink, frown, wrinkle forehead.
• ABNORMAL: Bell's Palsy
• Central Lesion of VII: The supratrochlear muscles are spared, as they receive bilateral innervation from both facial nerves. Below the eyes, the contralateral side will be paralyzed.
• Peripheral Lesion of VII: There is an entire facial hemiplegia, with the paralysis occurring on the contralateral side.
• CN VIII: VESTIBULOCOCHLEAR
• TEST: Standard hearing and vestibular tests.
• ABNORMAL: A variety of disorders
• CN IX: GLOSSOPHARYNGEAL
• TEST: Have patient open mouth and say "Aaahhh."
• ABNORMAL: See Vagus N. below.
• CN X: VAGUS
• TEST: Have patient open mouth and say "Aaahhh."
• ABNORMAL:
• Aortic Aneurysm, Bronchogenic Carcinoma may damage the recurrent laryngeal nerve.
• Uvula will deviate toward the damaged side.
• CN XI: SPINAL ACCESSORY
• TEST: Have patient shrug shoulders.
• ABNORMAL: Polymyositis
• CN XII: HYPOGLOSSAL
• TEST: Have patient stick out tongue.
• ABNORMAL:

MENTAL STATUS EXAM:

• STATE of CONSCIOUSNESS: The Glasgow Coma Scale
• ORIENTATION
• ABILITY to COOPERATE
• MOOD
• THOUGHT PROCESS
• MEMORY for RECENT and REMOTE EVENTS
• ABILITY to HANDLE CONCEPTS and PROVERBS
• PRACTICAL SKILLS
• SPEECH PROBLEMS and RECOGNITION of APHASIA

PATIENTS with ABNORMAL NEUROLOGICAL STATUS:

• APPROACH to the COMATOSE PATIENT:
• APPROACH to the DELIRIOUS PATIENT:
• APPROACH to the PATIENT with PERIPHERAL NEUROPATHY:
• APPROACH to the PATIENT with SIGNS of MENINGEAL IRRITATION:

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