- Kinetics of phase I-II biotransformation reactions in aquacultured fish species and in vitro metabolism of albendazole (Ph. D. project)
The aquaculture industry continues to be a growing sector throughout the world. This steady growth has been accomplished in part by the implementation of superintensive systems of production that rely on high stock densities of cultured specimens. Changes in optimal water physicochemical variables as well as proliferation of opportunistic pathogens deteriorate the fish health status leading to disease outbreaks and serious economic losses. However, only 6 drugs are currently approved by the FDA in the U.S. to cope with disease outbreaks. In part, the repertoire of drugs is not wider due to time-consuming and expensive approval process. My Ph.D. research project is intended to study biotransformation reactions in 8 aquacultured finfish species for a better understanding of similarities and differences in drug metabolism among the species. Albendazole, a broad spectrum antiparasitic, is being used as a model drug to compare metabolic capabilities in these species. The species that are being studied are: rainbow trout, Atlantic salmon, channel catfish, tilapia, striped bass, hybrid striped bass, bluegill and largemouth bass.
- Oxidative Stress Response in two indigenous fish species of Colombia due to waterborne exposure to endosulfan and glyphosate (Research Project funded by International Foundation of Science -IFS-)
Beginning September/2004, our research group will study oxidative stress (OS) responses in white cachama (Piaractus brachypomus) and bocachico (Prochilodus magdalenae) due to waterborne exposure to endosulfan and glyphosate. Indiscriminate use of these two pesticides in rural areas of Colombia has prompted serious concerns due to possible adverse effects on wildlife and human populations. We will use these two fish species as bioindicators of OS responses, a primary mechanism elicited by organisms to counteract cell injury caused by toxicants of this nature. OS response is mediated by enzymatic and non-enzymatic reactions. Fish specimens will be exposed to different concentrations of these pesticides under lab-controlled conditions. We expect to gather data that help us understand fundamental detoxification mechanisms and adaptive responses in native fish species of Colombia that are subject to environmental stressors.
