The routine use of a vaccine containing antibody to the Rho antigen in RH- women has greatly reduced the numbers of babies affected by isoimmunization. The current guidelines suggest the administration of this vaccine to pregnant women who are RH- at the following times:

• Between 28 and 32 weeks of pregnancy
  and
  
• Within 72 hours of giving birth
  and
  
• After any episode of vaginal bleeding throughout the pregnancy
  also
  
• After an abortion
  

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