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SKIN HYPERPIGMENTATION |
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generalised pigmentation: |
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endocrine disease: |
Addison's disease hyperthyroidism Nelson's syndrome [following adrenalectomy for Cushing's disease]Cushing's syndrome [cases with raised ACTH] |
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other / miscellaneous: |
normal in dark-skinned races or due to sun-tan pregnancy (chloasma, linea nigra, etc.)haemochromatosis ('bronze diabetes')uraemia (sallow complexion)heavy metal or arsenic poisoning Peutz-Jeghers syndrome (peri-oral pigmentation)Whipple's disease visceral leishmaniasis biliary cirrhosis |
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drugs: |
diethylstilbestrol steroids nicotinic acid (niacin) |
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localised pigmentation: |
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café au lait patches: |
neurofibromatosis very late in SBE |
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acanthosis nigricans: |
malignancy, esp. stomach (70%), colon and oesophaguspolycystic ovary syndrome insulin-resistant diabetes mellitus acromegaly Prader-Willi syndrome |
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other: |
following a severe dermatitis |
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