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SIDEROBLASTIC ANAEMIA |
[disordered iron metabolism; dyserythropoeisis causes excessive iron loading of red cell precursors; RING SIDEROBLASTS in bone marrow are diagnostic; widespread haemosiderosis may be present]
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hereditary [sex-linked benign disorder; much commoner in males; some respond to vitamin B6; low MCV] |
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acquired [high MCV]: |
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primary [group of idiopathic anaemias in elderly; 'idiopathic acquired sideroblastic anaemia'; one of the myelodysplastic syndromes; some develop into AML over years] |
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secondary: |
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inflammatory disease: |
rheumatoid arthritis systemic lupus erythematosus chronic infections |
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disease of bone marrow: |
myeloproliferative disorders, eg. PRV AML, other leukaemias multiple myeloma myelodysplastic syndromes myelosclerosis |
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other / miscellaneous: |
disseminated carcinoma megaloblastic anaemia, eg. pernicious anaemiamalabsorption syndrome myxoedema pregnancy haemolytic anaemias |
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drugs and toxins: |
pyrazinamide alcohol lead chloramphenicol isoniazid (pyridoxine (B6) deficiency) cycloserine |
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