PUO (pyrexia of undetermined origin)

infections (40%):

systemic:

miliary tuberculosis

infective endocarditis

brucellosis

psittacosis

CMV

EBV

HIV

salmonellosis

malaria

toxoplasmosis

many other infections

localised:

hepatic abscess

cholangitis

urinary tract infection

intra-peritoneal infections

dental infection

others

neoplasms (20%):

renal cell carcinoma

lymphomas

hepatocellular carcinoma

any other benign or malignant tumour

connective tissue disorders (20%):

rheumatic fever

systemic lupus erythematosus

rheumatoid arthritis

polyarteritis nodosa

giant cell arteritis

others

miscellaneous (10%):

drug fever

deep vein thrombosis

multiple pulmonary emboli

thyroiditis

inflammatory bowel disease

familial Mediterranean fever

factitious

unknown (10%)

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