OBESITY

endocrine disease:

hypothyroidism

hypogonadism, eg. Prader-Willi syndrome

hypopituitarism

Cushing's syndrome

polycystic disease of ovaries (Stein-Leventhal syndrome)

drugs:

steroids

oral contraceptive pill

insulin

phenothiazines

atypical neuroleptics, eg. olanzapine

tricyclic antidepressants

cerebral lesions increasing appetite:

post-encephalitis

cerebral sarcoidosis

hypothalamic lesions

psychiatric disease:

bulimia (some cases)

binge-eating disorder

night-eating syndrome

other: leptin deficiency (or receptor defects)

over-eating and/or decreased exercise (commonest cause)

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