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MONOCLONAL GAMMOPATHY (paraprotein or M-component on serum protein electrophoresis) |
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malignant plasma cell dyscrasias |
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multiple myeloma (IgG or IgA) Waldenstrom's macroglobulinaemia (IgM) solitary plasmacytoma |
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malignant lymphoreticular disorders |
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lymphoma chronic lymphocytic leukaemia hairy cell leukaemia other leukaemias |
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'benign monoclonal gammopathy' (monoclonal gammopathy of undetermined significance, MGUS) |
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immune reactions: |
immune deficiency autoimmune disease graft-versus-host disease drug hypersensitivity organ transplantation (including bone marrow) |
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infections: |
viral hepatitis cytomegalovirus toxoplasmosis Mycoplasma pneumoniae leptospirosis |
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tumours: |
melanoma parathyroid adenoma |
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skin disease: |
lichen myedoematosus (papular mucinosis) pyoderma gangrenosum necrobiotic xanthogranuloma |
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miscellaneous: |
silicone gel implants prosthetic valve primary amyloidosis idopathic (common in elderly) |
NB: monoclonal gammopathy is transient in temporary conditions (such as acute infections)
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