INCREASED GAS TRANSFER

TLCO always raised:

conditions causing pulmonary haemorrhage, eg. Goodpasture's syndrome

L to R shunts

polycythaemia

KCO normal; TLCO sometimes raised:

asthma

decreased TLCO, normal or raised KCO:

extrapulmonary restriction:

pleural disease

kyphoscoliosis

neuromuscular problems

normal KCO if remaining lung is normal:

pneumonectomy

NB: increased gas transfer = high TLCO, DLCO or KCO;

TLCO=CO transfer factor for whole lung (single breath CO transfer);

KCO=gas transfer coefficient (=TLCO/VA ), ie. it is corrected for lung volume.

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