|
IMMUNE HAEMOLYSIS [IMMUNE HAEMOLYTIC ANAEMIA] |
|
warm auto-antibodies [usually IgG; rarely IgA]: |
|
|
1� (idiopathic) |
|
|
2� to: |
lymphomas and other malignancies leukaemias, especially CLLsystemic lupus erythematosus and other connective tissue disease ulcerative colitis drugs (a -methyldopa, penicillins, quinidine) |
|
cold agglutinins (auto-antibodies)[IgM]: |
|
|
acute : |
associated with mycoplasma, EBV and other infections |
|
chronic: |
idiopathic associated with lymphoma |
|
cold haemolysins [IgG][= paroxysmal cold haemoglobinuria; auto-antibodies bind at low temperature and cause haemolysis when temperature rises to 30� C]: |
|
|
primary |
|
|
secondary to infection |
mycoplasma measles mumps other infections |
|
allo-immune (iso-immune) haemolysis: |
|
haemolytic transfusion reactions haemolytic disease of the newborn |
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