RAISED SERUM GASTRIN

(HYPERGASTRINAEMIA)

achlorhydria

proton pump inhibitors [gastrin level usually around 200-300 ng/l]

H2-receptor antagonists

Helicobacter pylori infection

gastric atrophy [gastrin level often > 1000 ng/l]

vagotomy

systemic conditions rheumatoid arthritis

Cushing's syndrome

phaeochromocytoma

renal failure

gastrinoma (Zollinger-Ellison syndrome) [gastrin level usually over 300 ng/l] sporadic

as part of MEN I (multiple endocrine neoplasia syndrome I)

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