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RAISED ALKALINE PHOSPHATASE |
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physiological: |
bone: |
preterm infants [up to 5X upper adult level]children until puberty [up to 2-3X]during puberty [up to 5-6X] |
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placenta: |
pregnancy, esp. 3rd trimester |
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bone: |
osteomalacia / rickets (hypovitaminosis D) Paget's disease of bone [ALP may be very high; all other biochemistry normal]metastatic bone disease extensive osteogenic sarcoma extensive 1° hyperparathyroidism [only slightly raised ALP] |
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liver: |
cholestasis space-occupying lesions, eg. tumour, granuloma, abscess, metastases |
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