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INTRAHEPATIC CHOLESTASIS |
[cholestatic picture = raised alkaline phosphatase and gamma-GT; raised bilirubin/jaundice if severe]
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primary liver disease: |
primary biliary cirrhosis (PBC) primary sclerosing cholangitis (PSC) |
|
| genetic disorders: |
benign recurrent intra-hepatic cholestasis Byler's disease (progressive familial intra-hepatic cholestasis) cystic fibrosis |
|
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miscellaneous causes: |
cholestasis of pregnancy chronic hepatitis B or C steato-hepatitis (alcoholic or other) severe sepsis graft-versus-host disease total parenteral nutrition (TPN) liver transplant rejection |
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drugs: |
co-amoxiclav flucloxacillin erythromycin tetracycline ciclosporin azathioprine chlorpromazine prochlorperazine tricyclic antidepressants cimetidine |
NSAIDs phenytoin carbamazepine barbiturates oestrogens anabolic steroids tamoxifen penicillamine tolbutamide others |
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