AMYLOIDOSIS

systemic (generalised amyloidosis):

immunocyte dyscrasias [1° amyloidosis (AL amyloid) associated with multiple myeloma]

reactive systemic amyloidosis [2° amyloidosis(AA amyloid)]:

chronic suppuration, eg. osteomyelitis

rheumatoid arthritis

leprosy (commonest cause world-wide)

inflammatory bowel disease

heredo-familial amyloidosis (familial amyloidotic neuropathies):

neuropathic forms (several), eg. Portuguese type [AFp amyloid]

non-neuropathic forms, eg. familial Mediterranean fever [AA amyloid]

haemodialysis-associated amyloidosis [b 2-microglobulin]

localised amyloidosis:

senile, eg. cardiac [ASc amyloid]

cerebral [in Alzheimer's disease]

isolated atrial amyloidosis

islets of Langerhans in NIDDM

endocrine, eg. associated with medullary carcinoma of thyroid [AEt amyloid]

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