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CGH is labeled as a fully penetrant, X-linked dominant disease. It affects males much more severely than it does in women. However, some families have reported cases in which family members possess symptoms strikingly similar to CGH and it is actually recessive. Geneticists have tried to give possible explanations for this. Some believe that a modifier gene on the X chromosome could be responsible. Others think that a gene on the X chromosome, paired with a deleted sequence on another gene, is waht causes the altered phenotype. Still others think that a mutation on the same gene is what causes the dominant trait to morph into a recessive one. Scientists remain confident in the fact that CGH is a fully penetrant dominant disorder, but other phenotypes can in rare cases arise recessively. |
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