proInsulin and related growth
factors
human..FVNQHL C GSHLVEALYLV
C GER GF
FYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQ
CC TSI C SLYQLENY C N
chimp AFVNQHL C GSHLVEALYLV C
GER GF FYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQ
CC TSI C SLYQLENY C N
macaqueFVNQHL C GSHLVEALYLV C GER GF FYTPKTRREAEDPQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQ
CC TSI C SLYQLENY C N
Fish ..APAQHL C GSHLVDALYLV C
GDR GF FYNPKRDVDQLLGFLPPKSGGAAAAGADNEVAE
.EMMVKRGIVEQ CC HRP C NIFDLQNY C N
....................................................................FAFKDQM
lance .TQAEYL C GSTLADVLSFV C
GNR GY NSQPRRSVSKRAIDFISEQ------QAKDYMGAMPHIRRRRGLVEE
CC YNV C DYSQLESY C N
Rodent FVNQHL C GSHLVEALYLV C
GER GF FYTPKFRRGVDDPQMPQLELGGSPGAGDLRALALEVARQKRGIVEQ
CC TGI C SLYQLENY C N
Pig ...FVNQHL C GSHLVEALYLV C
GER GF FYTPKARREAENPQAGAVELGGGLGG--LQALALEGPPQKRGIVEQ
CC TSI C SLYQLENY C N
Bovine FVNQHL C GSHLVEALYLV C
GER GF FYTPKARREVEGPQVGALELAGGPGAGG-----LEGPPQKRGIVEQ
CC ASV C SLYQLENY C N
Xeno1 .LANQHL C GSHLVEALYLV C
GDR GF FYYPKIKRDIEQAQVNGPQDNELDG---MQFQPQEYQKMKRGIVEQ
CC HST C SLFQLENY C N
Xeno2 .LVNQHL C GSHLVEALYLV C
GDR GF FYYPKVKRDMEQALVSGPQDNELDG---MQLQPQEYQKMKRGIVEQ
CC HST C SLFQLESY C N
hubir. AVNQHL C GSHLVEALYLV C
GER GF FYSPKARRDAEHPLVNGPLHGEVG---DLPFQQEEFEKVKRGIVEQ
CC HNT C SLYQLENY C N
TURTLE AANQHL C GSHLVEALYLV C
GER GF FYSPKA
..................................GIVEQ CC HNT C SLYQLENY C N
goose. AANQHL C GSHLVEALYLV C GER GF FYSPKT
..................................GIVEQ CC ENP C SLYQLENY C N
eel ...ASTQHL C GSHLVEALYLV C
GSN GF FFNPKD
..................................GIVEQ CC HKP C SIFDLQNY C N
Somatomedin A
HumanIGF-II AYRPSETL C GGELVDTLQFV C
GDR GF YFSRPA------SRVSRRSRGIVEE CC FRS C DLALLETY
C ATPAKSE
HorseIGF-II. . PSETL C GGELVDTLQFV C GDR GF YFSRPA------SRINRRSRGIVEE CC FRS C DLALLETY C
ATPAKSE
Pig Somatomedin B (residues 20-61 of pig vitronectin)
..Pig 20 ...............DQES C KGR C
TD GF
IAERK C Q C DEL C SYYQS CC TDYVAE C KP
human 20 ...............DQES C KGR C TE GF NVDKK C Q C DEL C SYYQS CC TDYTAE C KP
mouse 20 ...............DQES C KGR C TQ GF MASKK C Q C DEL C TYYQS CC ADYMEQ C K
Somatomedin C
Rabbit IGF-I ..GPETL C GAELVDALQFV
C
GDR GF
YFNKPT GY GSSSRRAPQTGIVDE CC FRS C DLRRLEMY C APLKPAKAA
...Dog IGF-I ..GPETL C GAELVDALQFV C GDR GF YFNKPT GY GSSSRRAPQTGIVDE CC FRS C DLRRLEMY C APLKPAKSA
.Human IGF-I ..GPETL C GAELVDALQFV C GDR GF YFNKPT GY GSSSRRAPQTGIVDE CC FRS C DLRRLEMY C APLKPAKSA
...Pig IGF-I ..GPETL C GAELVDALQFV C GDR GF YFNKPT GY GSSSRRAPQTGIVDE CC FRS C DLRRLEMY C APLKPAKSA
.Horse IGF-I ..GPETL C GAELVDALQFV C GDR GF YFNKPT GY GSSSRRAPQTGIVDE CC FRS C DLRRLEMY C APLKPAKSAR
J.QuailIGF-I ..GPETL C GAELVDALQFV C GDR GF YFSKPT GY GSSSRRLHHKGIVDE CC FQS C DLRRLEMY C APIKPPKSA
Human IGFII AYRPSETL C GGELVDTLQFV C GDR GF YFSRPA------SRVSRRSRGIVEE CC FRS C DLALLETY C ATPAKSE
Horse IGFII ...PSETL C GGELVDTLQFV C GDR GF YFSRPA------SRINRRSRGIVEE CC FRS C DLALLETY C ATPAKSE